N,N'-dimethylphthalamide

Base Information

• Chemical Name: N,N'-dimethylphthalamide
• CAS No.: 19532-98-0
• Molecular Formula: C10H12N2O2
• Molecular Weight: 192.217
• DSSTox Substance ID: DTXSID70412292
• Nikkaji Number: J1.327.355C
• Wikidata: Q82219580
• Mol file: 19532-98-0.mol

Synonyms:19532-98-0;N,N'-dimethylphthalamide;N1,N2-Dimethylphthalamide;1-N,2-N-dimethylbenzene-1,2-dicarboxamide;N1,N2-DIMETHYLBENZENE-1,2-DICARBOXAMIDE;1,2-Benzenedicarboxamide, N,N'-dimethyl-;n,n'-dimethyl phthalamide;SCHEMBL2344909;DTXSID70412292;OAJRKNFPHGSOSX-UHFFFAOYSA-N;AKOS027447545;AS-60075;CS-0018019;D93387;A934811

Chemical Property of N,N'-dimethylphthalamide

Chemical Property:

• Melting Point: 185 °C (decomp)
• Boiling Point: 453.0±28.0 °C(Predicted)
• PKA: 14.12±0.46(Predicted)
• PSA: 65.18000
• Density: 1.129±0.06 g/cm3(Predicted)
• LogP: 1.55540
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Very Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 192.089877630
• Heavy Atom Count: 14
• Complexity: 204

Purity/Quality:

97% ^*data from raw suppliers

N,N''-Dimethylphthalamide 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)C1=CC=CC=C1C(=O)NC
• Uses: N,N''-Dimethylphthalamide is a impurity derived from phthalamide (P384550). Phthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.

Technology Process of N,N'-dimethylphthalamide

There total 23 articles about N,N'-dimethylphthalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phthalimide (136918-14-4,85-41-6) + methylamine (74-89-5) → N1,N2-dimethylphthalamide (19532-98-0)

Guidance literature:

at -20 ℃; under 75.006 Torr;

DOI:10.1016/S0040-4020(00)00511-1

Reference yield: 100.0%

N-hydroxyphthalimide (524-38-9) + methylamine (74-89-5) → N1,N2-dimethylphthalamide (19532-98-0)

Guidance literature:

at 20 ℃; under 600.048 - 750.06 Torr;

DOI:10.1016/S0040-4020(00)00511-1

Reference yield: 100.0%

N-phthaloylglycine (4702-13-0) + methylamine (74-89-5) → N1,N2-dimethylphthalamide (19532-98-0)

Guidance literature:

at 20 ℃; under 600.048 - 750.06 Torr;

DOI:10.1016/S0040-4020(00)00511-1

upstream raw materials:

phthalimide

methylamine

N-methylphthalimide

N-methyl-phthalamide

Downstream raw materials:

N-methylphthalimide

N-methyl-phthalamide

Refernces

• 1、 Dragan, Andrei,Jones, D. Heulyn,Kennedy, Alan R.,Tomkinson, Nicholas C. O.. "Stereoselective Synthesis of Alkylidene Phthalides". . p. 3086 - 3089. Retrieved 2016/07/13.
• 2、 Kaupp, Gerd,Schmeyers, Jens,Boy, Juergen. "Quantitative solid-state reactions of amines with carbonyl compounds and isothiocyanates". . p. 6899 - 6911. Retrieved 2007/10/03.