METHYL 2-FLUORO-4-HYDROXYBENZOATE

Base Information

• Chemical Name: METHYL 2-FLUORO-4-HYDROXYBENZOATE
• CAS No.: 197507-22-5
• Molecular Formula: C8H7FO3
• Molecular Weight: 170.14
• Hs Code.: 2918290000
• Mol file: 197507-22-5.mol

Synonyms:methyl 2-fluoro-4-hydroxy-benzoate;Methyl 2-Fluoro-4-Hydroxybenzoate;2-fluoro-4-hydroxybenzoic acid methyl ester;2-fluoro-4-hyroxybenzoic acid methyl ester;

Chemical Property of METHYL 2-FLUORO-4-HYDROXYBENZOATE

Chemical Property:

• Vapor Pressure: 0.00152mmHg at 25°C
• Boiling Point: 286.6oC at 760 mmHg
• PKA: 7.36±0.18(Predicted)
• Flash Point: 127.1oC
• PSA: 46.53000
• Density: 1.309g/cm3
• LogP: 1.31790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoro-4-hydroxybenzoicAcidMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 2-fluoro-4-hydroxybenzoate can be used in the preparation of compounds, with the ability to inhibit cytosolic phospholipase A2α. It is also an intermediate in the synthesis of 3-(2-fluoro-4-hydroxyphenyl)-5-(trifluoromethyl) -4-isoxazolecarboxylic acid methyl ester (F591865).

Technology Process of METHYL 2-FLUORO-4-HYDROXYBENZOATE

There total 6 articles about METHYL 2-FLUORO-4-HYDROXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methanol (67-56-1) + 2-fluoro-4-hydroxybenzoic acid (65145-13-3) → methyl 2-fluoro-4-hydroxybenzoate (197507-22-5)

Guidance literature:

With sulfuric acid; at 90 ℃; for 16h;

Reference yield: 86.0%

2-fluoro-4-hydroxybenzoic acid (65145-13-3) → methyl 2-fluoro-4-hydroxybenzoate (197507-22-5)

Guidance literature:

Reference yield: 67.0%

4-chloro-2-fluorobenzoic acid methyl ester (148893-72-5) → methyl 2-fluoro-4-hydroxybenzoate (197507-22-5)

Guidance literature:

With formic acid; oxygen; triethylamine; copper(ll) bromide; In acetonitrile; at 20 ℃; for 48h; Irradiation;

DOI:10.1021/acs.orglett.7b03840

upstream raw materials:

2-fluoro-4-hydroxybenzoic acid

methanol

2-fluoro-4-methoxy-benzaldehyde

2-fluoro-4-methoxy-benzoic acid

Downstream raw materials:

2-fluoro-4-(furan-2-ylmethoxy)-benzoic acid methyl ester

2-fluoro-4-(thiazol-4-ylmethoxy)-benzoic acid methyl ester

methyl 2-fluoro-4-(((trifluoromethyl)sulfonyl)oxy)benzoate

methyl 5-(5,5-dimethylcyclopent-1-enyI)-2-fluoro-4-hydroxybenzoate

Refernces

• 1、 Buljan, An?ela,Kne?evi?, Anamarija,Dokli, Irena,Lesac, Andreja. "Synthesis and Mesomorphic Properties of Novel Bent-shaped Naphthyl Diketones". . p. 173 - 179. Retrieved 2019/12/12.
• 2、 Han, Chun-Chieh,Chou, Yu-Chaing,Chen, San-Yuan,Lin, Hong-Cheu. "Hydrogen-bonded bent-core blue phase liquid crystal complexes containing various molar ratios of proton acceptors and donors". . p. 32319 - 32327. Retrieved 2016/04/26.