2-ethoxy-2-oxo-1-phenylethyl benzoate

Base Information

• Chemical Name: 2-ethoxy-2-oxo-1-phenylethyl benzoate
• CAS No.: 73981-13-2
• Molecular Formula: C17H16O4
• Molecular Weight: 284.312
• Mol file: 73981-13-2.mol

Synonyms:

Chemical Property of 2-ethoxy-2-oxo-1-phenylethyl benzoate

Chemical Property:

• Vapor Pressure: 2.63E-07mmHg at 25°C
• Boiling Point: 421.3°C at 760 mmHg
• Flash Point: 211.1°C
• Density: 1.175g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethoxy-2-oxo-1-phenylethyl benzoate

There total 11 articles about 2-ethoxy-2-oxo-1-phenylethyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-phenyldiazoacetate (22065-57-2) + benzoic acid (65-85-0,8013-63-6) → 2-ethoxy-2-oxo-1-phenylethyl benzoate (73981-13-2)

Guidance literature:

With tropylium tetrafluoroborate; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04069

Reference yield: 92.0%

(1-ethoxy-2-phenylvinyloxy)trimethylsilane (31491-20-0) + lead(IV) tetrabenzoate (7717-48-8,15907-04-7,873-54-1) → ethyl 2-(benzoyloxy)-2-phenylacetate (73981-13-2)

Guidance literature:

With triethylamine hydrofluoride; In dichloromethane; 1.) 30 min, RT, 2.) 5-10 h, RT;

DOI:10.1021/jo00173a031

Reference yield: 83.0%

benzoyl chloride (98-88-4) + hydroxy-phenyl-acetic acid ethyl ester (774-40-3,4358-88-7) → 2-ethoxy-2-oxo-1-phenylethyl benzoate (73981-13-2)

Guidance literature:

With triethylamine; In chloroform; for 2h; Heating;

DOI:10.1021/jo960685e

upstream raw materials:

1-cyanobenzyl benzoate

benzoyl chloride

hydroxy-phenyl-acetic acid ethyl ester

phenylglyoxylic acid ethyl ester

Refernces

• 1、 Zeng, Linwei,Sajiki, Hironao,Cui, Sunliang. "One-Pot Reaction of Carboxylic Acids, Ynol Ethers, and m-CPBA for Synthesis of α-Carbonyloxy Esters". supporting information. p. 6423 - 6426. Retrieved 2019/08/21.
• 2、 Rubottom, George M.,Gruber, John M.,Marrero, Roberto,Juve, Henrik D.,Kim, Wan Chong. "Oxidation of Alkyl Trimethylsilyl Ketene Acetals with Lead(IV)". . p. 4940 - 4944. Retrieved 2007/10/02.