1-Methyl-1H-imidazole-2-carboxylic acid amide

Base Information

• Chemical Name: 1-Methyl-1H-imidazole-2-carboxylic acid amide
• CAS No.: 20062-51-5
• Molecular Formula: C5H7N3O
• Molecular Weight: 125.13
• Hs Code.: 2934999090
• Mol file: 20062-51-5.mol

Synonyms:Imidazole,2-aminocarbonyl-1-methyl;1-Methyl-1H-imidazole-2-carboxamide;1-methyl-1H-imidazole-2-carboxylic acid amide;1-methyl-2-imidazolecarboxamide;1-Methyl-2-carbamoyl-imidazol;

Chemical Property of 1-Methyl-1H-imidazole-2-carboxylic acid amide

Chemical Property:

• Melting Point: 165-167 °C
• Boiling Point: 313.3±25.0 °C(Predicted)
• PKA: 15.55±0.50(Predicted)
• PSA: 60.91000
• Density: 1.34±0.1 g/cm3(Predicted)
• LogP: 0.21930
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Methyl-1H-imidazole-2-carboxylicacidamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-1H-imidazole-2-carboxylic acid amide

There total 4 articles about 1-Methyl-1H-imidazole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-trichloroacetyl-1-methylimidazole (30148-23-3) → 1-methyl-1H-imidazole-2-carboxamide (20062-51-5)

Guidance literature:

With ammonium hydroxide; In acetonitrile; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmcl.2017.03.052

Reference yield: 84.0%

ethyl 1-methyl-1H-imidazole-2-carboxylate (30148-21-1) → 1-methyl-1H-imidazole-2-carboxamide (20062-51-5)

Guidance literature:

With ammonium hydroxide; In methanol; 1) 0 deg C, 2 h; 2) room temperature, overnight;

Reference yield: 53.0%

→ 1-methyl-1H-imidazole-2-carboxamide (20062-51-5)

Guidance literature:

upstream raw materials:

ethyl 1-methyl-1H-imidazole-2-carboxylate

2-trichloroacetyl-1-methylimidazole

1,2-dimethyl-1H-imidazole

Downstream raw materials:

1-Methyl-8-oxo-6-phenyl-7,8-dihydro-imidazo[1,2-a]pyrazin-1-ium; bromide

2-Carbamoyl-1-methyl-3-(2-oxo-2-phenyl-ethyl)-3H-imidazol-1-ium; bromide

6-phenylimidazo<1,2-a>pyrazin-8(7H)-one

1-methyl-1H-imidazole-2-carbonitrile

Refernces

• 1、 -. "METHOD FOR PRODUCING NITROGEN-CONTAINING AROMATIC AMIDE, METHOD FOR PRODUCING PYRROLE-IMIDAZOLE POLYAMIDE, AND COMPOUND". Paragraph 0269; 0270; 0271. . Retrieved 2019/04/05.
• 2、 -. "IMIDAZOPYRAZINE COMPOUNDS". Page/Page column 72-73. . Retrieved 2009/04/25.