Technology Process of 2,4-Pyrimidinediamine, 5-[(3-chloro-4,5-dimethoxyphenyl)methyl]-
There total 5 articles about 2,4-Pyrimidinediamine, 5-[(3-chloro-4,5-dimethoxyphenyl)methyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium ethanolate;
In
ethanol; dimethyl sulfoxide;
at 80 ℃;
for 16h;
Inert atmosphere;
DOI:10.1016/j.bmc.2018.05.019
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; tetra-(n-butyl)ammonium iodide / dichloromethane; water / Inert atmosphere
1.2: 16 h / 20 °C / Inert atmosphere
2.1: sodium methylate / dimethyl sulfoxide / 0.75 h / 65 - 80 °C / Inert atmosphere
2.2: 16 h / 80 °C / Inert atmosphere
3.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere
With
sodium methylate; sodium ethanolate; tetra-(n-butyl)ammonium iodide; sodium hydroxide;
In
ethanol; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2018.05.019
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium methylate / dimethyl sulfoxide / 0.75 h / 65 - 80 °C / Inert atmosphere
1.2: 16 h / 80 °C / Inert atmosphere
2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere
With
sodium methylate; sodium ethanolate;
In
ethanol; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2018.05.019