RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE

Base Information

• Chemical Name: RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE
• CAS No.: 20297-37-4
• Molecular Formula: C6H10N2
• Molecular Weight: 110.159
• Mol file: 20297-37-4.mol

Synonyms:1-methyl-pyrrolidine,picrate;N-Methyl-2-cyano-pyrrolidin;N-methyl-2-cyanopyrrolidine;1-Methyl-2-cyano-pyrrolidin;N-Methyl-pyrrolidin-2-nitril;2,4,6-trinitrophenol-1-methylpyrrolidine(1:1);N-methylpyrrolidinium picrate;1-methylpyrrolidine-2-carbonitrile;1-Methyl-pyrrolidin,Picrat;1-methyl-2-cyanopyrrolidine;

Chemical Property of RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE

Chemical Property:

• Vapor Pressure: 0.589mmHg at 25°C
• Boiling Point: 188.792oC at 760 mmHg
• PKA: 6.86±0.40(Predicted)
• Flash Point: 68.906oC
• PSA: 27.03000
• Density: 1g/cm3
• LogP: 0.54208

Purity/Quality:

95% ^*data from raw suppliers

rac1-Methyl-pyrrolidine-2-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE

There total 3 articles about RAC 1-METHYL-PYRROLIDINE-2-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methylpyrrolidine (120-94-5) + sodium cyanide (143-33-9,25596-52-5) → N-cyanomethyl pyrrolidine (29134-29-0) + 1-methyl-2-pyrrolidinecarbonitrile (20297-37-4)

Guidance literature:

With chlorine dioxide; In water; acetonitrile; at 0 - 25 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja00222a052

Reference yield:

1-Methylpyrrolidine (120-94-5) → N-cyanomethyl pyrrolidine (29134-29-0) + 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 1-methyl-2-pyrrolidinecarbonitrile (20297-37-4) + N-methylpyrrolidine N-oxide (7529-17-1)

Guidance literature:

With potassium cyanide; oxygen; In water; at 80 ℃; for 48h; under 1520 Torr; Title compound not separated from byproducts;

Reference yield:

1-Methylpyrrolidine (120-94-5) + potassium cyanide (151-50-8) → N-cyanomethyl pyrrolidine (29134-29-0) + 1-methyl-pyrrolidin-2-one (872-50-4,26138-58-9) + 1-methyl-2-pyrrolidinecarbonitrile (20297-37-4) + N-methylpyrrolidine N-oxide (7529-17-1)

Guidance literature:

With oxygen; In water; at 80 ℃; for 48h; under 1520 Torr; Title compound not separated from byproducts;

upstream raw materials:

1-Methylpyrrolidine

sodium cyanide

potassium cyanide

Downstream raw materials:

2-cyano-1,1-dimethylpyrrolidinium p-toluenesulfonate

2-(1-methylpyrrolidin-2-yl)-1-(3,4-dimethoxyphenyl )ethanone

Refernces

• 1、 Beckwith, Athelstan L. J.,Eichinger, Peter H.,Mooney, Brett A.,Prager, Rolf H.. "Amine Autoxidation in Aqueous Solution". . p. 719 - 739. Retrieved 2007/10/02.