1-BOC-(2S)-[N-METHOXY-N-METHYLCARBAMOYL]PIPERIDINE

Base Information

• Chemical Name: 1-BOC-(2S)-[N-METHOXY-N-METHYLCARBAMOYL]PIPERIDINE
• CAS No.: 203056-27-3
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.345
• Mol file: 203056-27-3.mol

Synonyms:1,1-dimethylethyl (2S)-2-(N-methoxy-N-methylcarbamoyl)piperidine-1-carboxylate;1,1-dimethylethyl(2S)-2-(N-methoxy-N-methylcarbamoyl)piperidine-1-carboxylate;tert-butyl (2S)-2-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate;(S)-2-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl (S)-2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate;tert-butyl (2S)-2-(N-methoxy-N-methyl-carbamoyl)piperidine-1-carboxylate;tert-butyl (2S)-2-((methoxy(methyl)amino)carbonyl)piperidine-1-carboxylate;

Chemical Property of 1-BOC-(2S)-[N-METHOXY-N-METHYLCARBAMOYL]PIPERIDINE

Chemical Property:

• PSA: 59.08000
• LogP: 1.73370

Purity/Quality:

95%-98% ^*data from raw suppliers

(S)-tert-butyl2-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-(2S)-[N-METHOXY-N-METHYLCARBAMOYL]PIPERIDINE

There total 7 articles about 1-BOC-(2S)-[N-METHOXY-N-METHYLCARBAMOYL]PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate (203056-27-3)

Guidance literature:

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 6h;

DOI:10.1021/jm970620j

Reference yield: 89.0%

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) + N,0-dimethylhydroxylamine (1117-97-1) → tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate (203056-27-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield: 83.0%

Ν,Ο-dimethylhydroxylamine hydrochloride + (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid (26250-84-0) → tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate (203056-27-3)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; for 6h; Inert atmosphere;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

N,0-dimethylhydroxylamine

di-tert-butyl dicarbonate

Downstream raw materials:

(2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-bromophenyl ketone

(2S)-N-(tert-butyloxycarbonyl)piperidin-2-yl 4-methoxyphenyl ketone

(S)-N-(tert-butyloxycarbonyl)piperidin-2-yl-phenylmethanone

(S)-1-N-Boc-piperidine-2-al

Refernces

• 1、 -. "Compound, preparation method thereof, pharmaceutical composition and application of compound". Paragraph 0315-0318. . Retrieved 2020/01/03.
• 2、 -. "Pyrazolo[1,5-A]pyrimidines as antiviral agents". Page/Page column 213. . Retrieved 2016/04/20.