ethyl 2-benzylacrylate

Base Information

• Chemical Name: ethyl 2-benzylacrylate
• CAS No.: 20593-63-9
• Molecular Formula: C12H14O2
• Molecular Weight: 190.242
• Mol file: 20593-63-9.mol

Synonyms:2-BENZYLACRYLIC ACID ETHYL ESTER;

Chemical Property of ethyl 2-benzylacrylate

Chemical Property:

• PSA: 26.30000
• LogP: 2.34840

Purity/Quality:

95% ^*data from raw suppliers

A-METHYLENE-BENZENEPROPANOIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-benzylacrylate

There total 69 articles about ethyl 2-benzylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Ethyl 2-benzylacetoacetate (620-79-1) → 2-Benzylacrylic acid ethyl ester (20593-63-9)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 6h;

DOI:10.1021/jo026738b

Reference yield: 86.0%

ethanol (64-17-5) + 2-Benzyl-2-propenoic acid (5669-19-2) → 2-Benzylacrylic acid ethyl ester (20593-63-9)

Guidance literature:

With thionyl chloride; at 80 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.bmc.2009.06.065

Reference yield: 85.0%

piperidine (110-89-4) + diethyl 2-benzylmalonate (607-81-8) → 2-Benzylacrylic acid ethyl ester (20593-63-9)

Guidance literature:

With pyridine; potassium hydroxide; paraformaldehyde; In hydrogenchloride; ethanol; hexane; water;

upstream raw materials:

ethyl 3-hydroxy-2-methyl-2-phenylpropanoate

formaldehyd

Ethyl 2-benzylacetoacetate

(2-Ethoxycarbonyl-2-methoxycarbonyl-3-phenyl-propyl)-trimethyl-ammonium; iodide

Downstream raw materials:

2-benzylallyl alcohol

α-[[(1,1-dimethylethyl)-thio]methyl]benzenepropanoic acid,ethyl ester

2-Benzyl-3-[hydroxy-((S)-1-phenyl-ethyl)-amino]-propionic acid ethyl ester

ethyl 3-(acetylthio)-2-benzylpropanoate

Refernces

• 1、 Ji, Xiaolei,Shen, Chaoren,Tian, Xinxin,Dong, Kaiwu. "Palladium-Catalyzed Asymmetric Hydroesterification of α-Aryl Acrylic Acids to Chiral Substituted Succinates". . p. 8645 - 8649. Retrieved 2021/10/25.
• 2、 Schade, Markus,Merla, Beatrix,Lesch, Bernhard,Wagener, Markus,Timmermanns, Simone,Pletinckx, Katrien,Hertrampf, Torsten. "Highly Selective Sub-Nanomolar Cathepsin S Inhibitors by Merging Fragment Binders with Nitrile Inhibitors". supporting information. p. 11801 - 11808. Retrieved 2020/11/26.