4-Phenyloxazole

Base Information

• Chemical Name: 4-Phenyloxazole
• CAS No.: 20662-89-9
• Molecular Formula: C9H7NO
• Molecular Weight: 145.161
• Hs Code.: 2934999090
• Mol file: 20662-89-9.mol

Synonyms:Oxazole,4-phenyl;4-Phenyloxazol;4-Phenyloxazole;

Chemical Property of 4-Phenyloxazole

Chemical Property:

• Vapor Pressure: 0.0186mmHg at 25°C
• Melting Point: 116-119℃
• Boiling Point: 261.6oC at 760 mmHg
• PKA: 0.26±0.10(Predicted)
• Flash Point: 102.8oC
• PSA: 26.03000
• Density: 1.11g/cm3
• LogP: 2.34160
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Phenyloxazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Phenyloxazole

There total 16 articles about 4-Phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-phenyl-2H-azirine-2-carboxaldehyde (42970-55-8) → 4-phenyl-1,3-oxazole (20662-89-9)

Guidance literature:

With boron trifluoride diethyl etherate; In diethyl ether; at -50 - 20 ℃; for 0.333333h;

DOI:10.1002/jhet.5570450203

Reference yield: 94.0%

4-phenylisoxazole (2439-92-1) → 4-phenyl-1,3-oxazole (20662-89-9)

Guidance literature:

In methanol; for 0.0833333h; Irradiation;

DOI:10.1002/jhet.5570420215

Reference yield: 76.0%

Methyl formate (107-31-3) + Benzyl isocyanide (88333-03-3,10340-91-7) → 4-phenyl-1,3-oxazole (20662-89-9)

Guidance literature:

Benzyl isocyanide; With n-butyllithium; In tetrahydrofuran; at -78 ℃;

Methyl formate;

With acetic acid;

DOI:10.1002/ejoc.201900032

upstream raw materials:

formamide

α-bromoacetophenone

2-phenyloxazole

Methyl formate

Downstream raw materials:

6-phenyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-epioxido-pyrrolo[3,4-c]pyridine-1,3-dione

2-ethyl-6-phenyl-(3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-epioxido-pyrrolo[3,4-c]pyridine-1,3-dione

2-chloro-4-phenyloxazole

4-[4-(4-phenyloxazol-2-yl)phenoxy]-(methoxy)benzene

Refernces

• 1、 Solomin, Vitalii V.,Radchenko, Dmytro S.,Slobodyanyuk, Evgeniy Y.,Geraschenko, Oleksandr V.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.. "Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks". . p. 2884 - 2898. Retrieved 2019/03/07.
• 2、 Perner, Richard J.,Koenig, John R.,Didomenico, Stanley,Gomtsyan, Arthur,Schmidt, Robert G.,Lee, Chih-Hung,Hsu, Margaret C.,McDonald, Heath A.,Gauvin, Donna M.,Joshi, Shailen,Turner, Teresa M.,Reilly, Regina M.,Kym, Philip R.,Kort, Michael E.. "Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists". scheme or table. p. 4821 - 4829. Retrieved 2010/08/06.