2-Ethyl-4,5-diphenyloxazole

Base Information

• Chemical Name: 2-Ethyl-4,5-diphenyloxazole
• CAS No.: 20662-94-6
• Molecular Formula: C17H15NO
• Molecular Weight: 249.312
• Mol file: 20662-94-6.mol

Synonyms:2-Aethyl-4,5-diphenyl-oxazol;2-ethyl-4,5-diphenyloxazole;Oxazole,2-ethyl-4,5-diphenyl;

Chemical Property of 2-Ethyl-4,5-diphenyloxazole

Chemical Property:

• Melting Point: 31-32 °C(Solv: benzene (71-43-2); hexane (110-54-3))
• Boiling Point: 110-125 °C(Press: 0.3 Torr)
• PKA: 1.24±0.10(Predicted)
• PSA: 26.03000
• Density: 1.089±0.06 g/cm3(Predicted)
• LogP: 4.57100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Ethyl-4,5-diphenyloxazole

There total 15 articles about 2-Ethyl-4,5-diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4,5-diphenyl-2-(1-(phenylsulfonyl)ethyl)oxazole → 2-ethyl-4,5-diphenyloxazole (20662-94-6)

Guidance literature:

With aluminium hydride; mercury dichloride; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.joc.6b01280

Reference yield: 95.5%

2-methylthio-4,5-diphenyl-1,3-oxazole (14725-35-0) + ethylmagnesium bromide (925-90-6) → 2-ethyl-4,5-diphenyloxazole (20662-94-6)

Guidance literature:

1,2-bis(diphenylphosphino)ethane nickel(II) chloride; In tetrahydrofuran; diethyl ether; for 18h; Ambient temperature;

DOI:10.1055/s-1984-31074

Reference yield: 85.0%

α-propionyloxy-deoxybenzoin (53901-50-1) → 2-ethyl-4,5-diphenyloxazole (20662-94-6)

Guidance literature:

With sulfuric acid; formamide; 1.) 110 deg C, 1 h, 2.) 140-150 deg C, 2 h;

DOI:10.1055/s-1998-6093

upstream raw materials:

α-propionyloxy-deoxybenzoin

2-methyl-4,5-diphenyloxazole

methyl iodide

2-methylthio-4,5-diphenyl-1,3-oxazole

Downstream raw materials:

N-propionyl-benzamide

Refernces

• 1、 -. "METHOD FOR PRODUCING OXAZOLE COMPOUND". Paragraph 0049;0053-0054. . Retrieved 2016/10/10.
• 2、 Lai, Ping-Shan,Taylor, Mark S.. "Preparation of substituted oxazoles by ritter reactions of α-oxo tosylates". experimental part. p. 1449 - 1452. Retrieved 2010/09/14.