5-Chloronaphthalen-1-ol

Base Information

• Chemical Name: 5-Chloronaphthalen-1-ol
• CAS No.: 20816-76-6
• Molecular Formula: C10H7ClO
• Molecular Weight: 178.618
• DSSTox Substance ID: DTXSID10491405
• Wikidata: Q82335939
• Mol file: 20816-76-6.mol

Synonyms:5-chloronaphthalen-1-ol;20816-76-6;5-Chloro-1-kydroxynaphthalene;5-chloro-1-naphthalenol;1-Naphthalenol, 5-chloro-;SCHEMBL4960152;DTXSID10491405;MFCD02179788;BS-28131;FT-0769721;E80257

Chemical Property of 5-Chloronaphthalen-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 3.19880
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 178.0185425
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

97% ^*data from raw suppliers

5-Chloro-1-kydroxynaphthalene 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC2=C(C=CC=C2Cl)C(=C1)O

Technology Process of 5-Chloronaphthalen-1-ol

There total 7 articles about 5-Chloronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

5-chloro-3,4-dihydro-1(2H)-naphthalenone (26673-30-3) → 5-chloro-1-naphthalenol (20816-76-6)

Guidance literature:

With (difluoroboryl)dimethylglyoximatocobalt(II) bis(acetonitrile); boron trifluoride diethyl etherate; 3-cyano-N-methyl-quinolinium perchlorate; In acetonitrile; at 20 ℃; for 0.5h; Irradiation; Inert atmosphere; Flow reactor;

DOI:10.1039/c9cy00753a

Reference yield:

8-Chloro-4-methoxy-naphthalene-2-carboxylic acid (91498-80-5) → 5-chloro-1-naphthalenol (20816-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper-bronze / quinoline / Heating

2: HI

With hydrogen iodide; copper; In quinoline;

DOI:10.1021/jo01070a021

Reference yield:

→ 5-chloro-1-naphthalenol (20816-76-6)

Guidance literature:

Hydrolysis;

DOI:10.1021/ja01122a011

upstream raw materials:

1-chloro-5-methoxynaphthalene

8-Chloro-4-methoxy-naphthalene-2-carboxylic acid

5-chloro-3,4-dihydro-1(2H)-naphthalenone

Downstream raw materials:

5-chloro-2-[dimethylamino-(2-methoxyphenyl)-methyl]-naphthalen-1-ol

1,5-dichloronaphthalene

Refernces

• 1、 He, Xu,Zheng, Yi-Wen,Lei, Tao,Liu, Wen-Qiang,Chen, Bin,Feng, Ke,Tung, Chen-Ho,Wu, Li-Zhu. "Photocatalytic hydrogen evolution of 1-tetralones to α-naphthols by continuous-flow technology". . p. 3337 - 3341. Retrieved 2019/07/10.