(3-Hydroxy-2,2,5,5-tetramethylpyrrolizinooxy)radical

Base Information

• Chemical Name: (3-Hydroxy-2,2,5,5-tetramethylpyrrolizinooxy)radical
• CAS No.: 2154-37-2
• Molecular Formula: C8H16NO2
• Molecular Weight: 158.21800
• Mol file: 2154-37-2.mol

Synonyms:3-hydroxy-2,2,5,5-tetramethylpyrrolidinyloxy;

Chemical Property of (3-Hydroxy-2,2,5,5-tetramethylpyrrolizinooxy)radical

Chemical Property:

• PSA: 49.66000
• LogP: 1.04590

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-Hydroxy-2,2,5,5-tetramethylpyrrolizinooxy)radical

There total 7 articles about (3-Hydroxy-2,2,5,5-tetramethylpyrrolizinooxy)radical which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-one (2154-34-9) → 3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl (2154-37-2)

Guidance literature:

With sodium tetrahydroborate; In methanol; water; at 25 ℃; for 8h;

DOI:10.1016/S0040-4020(01)96516-0

Reference yield:

2,2,5,5-tetramethyl-3-oxopyrrolidine (5167-85-1) → 3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl (2154-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 30percent H₂O₂, Na₂WO₄ / H₂O

2: 95 percent / NaBH₄ / methanol; H₂O / 8 h / 25 °C

With sodium tetrahydroborate; sodium tungstate; dihydrogen peroxide; In methanol; water;

DOI:10.1016/S0040-4020(01)96516-0

Reference yield:

2,2,6,6-Tetramethyl-4-piperidone (826-36-8) → 3-hydroxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl (2154-37-2)

Guidance literature:

Multi-step reaction with 5 steps

1: Br₂ / acetic acid

2: NH₄OAc

3: NaOBr / H₂O

4: 30percent H₂O₂, Na₂WO₄ / H₂O

5: 95 percent / NaBH₄ / methanol; H₂O / 8 h / 25 °C

With sodium tetrahydroborate; sodium tungstate; sodium hypobromide; ammonium acetate; dihydrogen peroxide; bromine; In methanol; water; acetic acid;

DOI:10.1016/S0040-4020(01)96516-0

upstream raw materials:

2,2,5,5-tetramethylpyrrolidin-1-oxyl-3-one

3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy

2,2,5,5-tetramethyl-3-oxopyrrolidine

2,2,6,6-Tetramethyl-4-piperidone

Downstream raw materials:

3-hydroxy-2,2,5,5-tetramethyl-1-pyrrolidinyloxy

Azobenzene

Refernces

• 1、 Kosman,Piette. "". . p. 926. Retrieved 1969.
• 2、 Couet, W. R.,Brasch, R. C.,Sosnovsky, G.,Lukszo, J.,Prakash, I.,et. al.. "INFLUENCE OF CHEMICAL STRUCTURE OF NITROXYL SPIN LABELS ON THEIR REDUCTION BY ASCORBIC ACID". . p. 1165 - 1172. Retrieved 2007/10/02.