Phosphorous acid, ethyl diphenyl ester

Base Information

• Chemical Name: Phosphorous acid, ethyl diphenyl ester
• CAS No.: 2161-16-2
• Molecular Formula: C14H15O3P
• Molecular Weight: 262.245
• Mol file: 2161-16-2.mol

Synonyms:diphenylethyl phosphite;ethyl diphenyl phosphite;

Chemical Property of Phosphorous acid, ethyl diphenyl ester

Chemical Property:

• PSA: 41.28000
• LogP: 4.40780

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphorous acid, ethyl diphenyl ester

There total 7 articles about Phosphorous acid, ethyl diphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

phosphorodichloridous acid ethyl ester (1498-42-6) + phenol (108-95-2,27073-41-2) → phosphorous acid ethyl ester-diphenyl ester (2161-16-2)

Guidance literature:

With triethylamine; In diethyl ether; toluene; at 0 - 20 ℃; for 3.5h;

DOI:10.1002/ejoc.200400769

Reference yield:

ethanol (64-17-5) + diphenyl hydrogen phosphite (4712-55-4) → triphenyl phosphite (101-02-0) + phosphorous acid ethyl ester-diphenyl ester (2161-16-2)

Guidance literature:

With pyridine; pivaloyl chloride; Multistep reaction;

DOI:10.1016/0040-4020(96)00525-X

Reference yield:

Diphenyl phosphorochloridite (5382-00-3) → phosphorous acid ethyl ester-diphenyl ester (2161-16-2)

Guidance literature:

With pyridine; diethyl ether; ethanol;

DOI:10.1021/ja01591a081

upstream raw materials:

Diphenyl phosphorochloridite

ethanol

diphenyl hydrogen phosphite

phosphorodichloridous acid ethyl ester

Downstream raw materials:

diphenyl (ethoxycarbonyl)phosphonate

Iodmethanphosphonsaeurediphenylester

(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-phosphonic acid diphenyl ester

(4R)-N-benzyl-N-(tert-butyloxycarbonyl)-2,2-dibenzyl-4-diphenylphosphatoxy-5-methyl-5-nitrohexylamine

Refernces

• 1、 Quintiliani, Maurizio,Balzarini, Jan,McGuigan, Christopher. "Design, synthesis, and biological evaluation of C1-phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate". . p. 9111 - 9119. Retrieved 2013/09/24.
• 2、 Kers, Annika,Kers, Inger,Stawinski, Jacek,Sobkowski, Michal,Kraszewski, Adam. "Studies on aryl H-phosphonates. 3. Mechanistic investigations related to the disproportionation of diphenyl H-phosphonate under anhydrous basic conditions". . p. 9931 - 9944. Retrieved 2007/10/03.