Α-METHYLCINNAMALDEHYDE

Base Information

• Chemical Name: Α-METHYLCINNAMALDEHYDE
• CAS No.: 21866-70-6
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.189
• Mol file: 21866-70-6.mol

Synonyms:

Chemical Property of Α-METHYLCINNAMALDEHYDE

Chemical Property:

• Refractive Index: n20/D 1.6045
• Boiling Point: 148-149?°C/27?mmHg
• Flash Point: 79?°C
• Density: 1.037?g/mL?at 25?°C

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Α-METHYLCINNAMALDEHYDE

There total 91 articles about Α-METHYLCINNAMALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-[(1E)-1-methyl-1,3-butadienyl]benzene (55177-38-3) → (E)-β-methylcinnamaldehyde (1196-67-4,21878-52-4,21866-70-6)

Guidance literature:

With iron(III) sulfate hydrate; oxygen; In water; acetonitrile; at 45 ℃; for 22h; regioselective reaction;

DOI:10.1021/acs.orglett.9b03562

Reference yield: 86.0%

2-Phenyl-3-butyn-2-ol (127-66-2) → (Z)-3-Phenyl-but-2-en-1-al (1196-67-4,21866-70-6,21878-52-4) + (E)-β-methylcinnamaldehyde (1196-67-4,21878-52-4,21866-70-6)

Guidance literature:

With iron(III) chloride hexahydrate; In glycerol; at 25 ℃; for 0.166667h;

DOI:10.1039/d0cc06584f

Reference yield: 86.0%

2-Phenyl-3-butyn-2-ol (127-66-2) → (Z)-3-Phenyl-but-2-en-1-al (1196-67-4,21866-70-6,21878-52-4) + (E)-β-methylcinnamaldehyde (1196-67-4,21878-52-4,21866-70-6)

Guidance literature:

With iron(III) chloride hexahydrate; In glycerol; at 25 ℃; for 0.166667h;

DOI:10.1039/d0cc06584f

upstream raw materials:

2-Phenyl-3-butyn-2-ol

iodobenzene

2,3-butadien-1-ol

-butyl vinyl ether

Downstream raw materials:

(3Z,5E)-6-Phenyl-hepta-3,5-dienoic acid cyclohexylamide

(3E,5E)-6-Phenyl-hepta-3,5-dienoic acid cyclohexylamide

(2S,4aS,7R,8aR)-4,4,7-Trimethyl-2-((E)-2-phenyl-propenyl)-octahydro-benzo[e][1,3]oxazine

(1S,4R,6R,8R)-11,11-dimethyl-4-[(E)-2-phenyl-propenyl]-5-oxa-3-thia-tricyclo[6.2.1.0^1,6]undecane

Refernces

• 1、 -. "Method for preparing olefine aldehyde through catalytic oxidation of enol ether". Paragraph 0082-0086; 0088. . Retrieved 2021/06/23.
• 2、 Wu, Qiuyue,Dong, Ziyang,Xu, Jiaxi,Yang, Zhanhui. "Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights". supporting information. p. 3173 - 3180. Retrieved 2021/04/21.