N-(4-Chlorophenyl)-2-hydroxyacetamide

Base Information

• Chemical Name: N-(4-Chlorophenyl)-2-hydroxyacetamide
• CAS No.: 21919-09-5
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.60800
• European Community (EC) Number: 821-210-6
• Nikkaji Number: J391.076H
• Mol file: 21919-09-5.mol

Synonyms:N-(4-CHLOROPHENYL)-2-HYDROXYACETAMIDE;21919-09-5;p-Chloroglycolanilide;SCHEMBL2098194;ICNZEQVGQKOBJJ-UHFFFAOYSA-N;AKOS000126379;CS-0245107;EN300-299320;G40174;Z228585484

Chemical Property of N-(4-Chlorophenyl)-2-hydroxyacetamide

Chemical Property:

• PSA: 49.33000
• LogP: 1.34380
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 185.0243562
• Heavy Atom Count: 12
• Complexity: 155

Purity/Quality:

95% ^*data from raw suppliers

N-(4-CHLOROPHENYL)-2-HYDROXYACETAMIDE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1NC(=O)CO)Cl

Technology Process of N-(4-Chlorophenyl)-2-hydroxyacetamide

There total 2 articles about N-(4-Chlorophenyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycolic Acid (79-14-1) + N-(4-chloro-phenyl)-sulfur imide oxide (13165-68-9,52867-11-5) → glycolic acid-(4-chloro-anilide) (21919-09-5)

Guidance literature:

at 25 ℃; for 6h;

DOI:10.1016/S0040-4039(00)84412-3

Reference yield:

glycolic Acid (79-14-1) + 4-chloro-aniline (106-47-8) → glycolic acid-(4-chloro-anilide) (21919-09-5)

Guidance literature:

DOI:10.1021/ja01532a052

Reference yield:

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + 4,4'-bis(dimethylamino)benzhydrol (119-58-4) + glycolic acid-(4-chloro-anilide) (21919-09-5) → 4'Chloro-2[-bis(p-dimethylaminophenyl)methoxy]acetanilide

Guidance literature:

With N,N,N₁,N₁-tetramethylguanidine; In hexane; acetic acid;

upstream raw materials:

glycolic Acid

4-chloro-aniline

N-(4-chloro-phenyl)-sulfur imide oxide

Downstream raw materials:

methoxycarbonyloxy-acetic acid-(4-chloro-anilide)

Refernces