2'-Methoxy-2-phenylacetophenone

Base Information

• Chemical Name: 2'-Methoxy-2-phenylacetophenone
• CAS No.: 33470-10-9
• Molecular Formula: C15H14 O2
• Molecular Weight: 226.275
• Hs Code.: 2914509090
• NSC Number: 55786
• DSSTox Substance ID: DTXSID50288417
• Nikkaji Number: J864.459D
• Wikidata: Q82024813
• ChEMBL ID: CHEMBL1872268
• Mol file: 33470-10-9.mol

Synonyms:2'-Methoxy-2-phenylacetophenone;33470-10-9;1-(2-methoxyphenyl)-2-phenylethanone;MLS002667768;MFCD02260671;NSC55786;2-methoxyphenyl benzyl ketone;SCHEMBL3282912;CHEMBL1872268;DTXSID50288417;HMS3089H15;NSC-55786;AKOS005911397;BS-17044;SMR001557527;CS-0150316;C74717

Chemical Property of 2'-Methoxy-2-phenylacetophenone

Chemical Property:

• Vapor Pressure: 2.76E-05mmHg at 25°C
• Boiling Point: 357.3°C at 760 mmHg
• Flash Point: 158.1°C
• PSA: 26.30000
• Density: 1.1g/cm³
• LogP: 3.12060
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 226.099379685
• Heavy Atom Count: 17
• Complexity: 243

Purity/Quality:

99% ^*data from raw suppliers

2'-Methoxy-2-phenylacetophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1C(=O)CC2=CC=CC=C2

Technology Process of 2'-Methoxy-2-phenylacetophenone

There total 34 articles about 2'-Methoxy-2-phenylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

phenyldiazomethane (908094-04-2) + ortho-anisaldehyde (135-02-4) → 1-(2-methoxyphenyl)-2-phenylethanone (33470-10-9)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In toluene; at -78 ℃; for 0.166667h; Inert atmosphere;

DOI:10.1021/ol9010932

Reference yield: 94.0%

N-[1-Cyano-1-(2-methoxy-phenyl)-2-phenyl-ethyl]-N-phenyl-benzamide (72867-68-6) → 1-(2-methoxyphenyl)-2-phenylethanone (33470-10-9)

Guidance literature:

With potassium hydroxide; In ethanol; water; Heating;

DOI:10.1021/jo01295a027

Reference yield: 92.0%

2-Methoxyacetophenone (579-74-8) + bromobenzene (108-86-1,52753-63-6) → 1-(2-methoxyphenyl)-2-phenylethanone (33470-10-9)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate; In tetrahydrofuran; at 70 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201309114

upstream raw materials:

2-amino-1-(2-methoxy-phenyl)-1-phenyl-ethanol

3-(2-methoxy-phenyl)-3-oxo-2-phenyl-propionitrile

2-methoxy-benzonitrile

benzylmagnesium chloride

Downstream raw materials:

2-methoxy-α-phenyl-α-diazoacetophenone

2-phenyl-3(2H)-benzxofuranone

isoflavone

2-methoxybenzil

Refernces

• 1、 Gu, Yuanyun,Zhang, Zhen,Wang, Yan-En,Dai, Ziteng,Yuan, Yaqi,Xiong, Dan,Li, Jie,Walsh, Patrick J.,Mao, Jianyou. "Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System". supporting information. p. 406 - 418. Retrieved 2022/01/14.
• 2、 Tang, Shuang-Qi,Bricard, Jacques,Schmitt, Martine,Bihel, Frédéric. "Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP". . p. 844 - 848. Retrieved 2019/01/30.