1-Methyl-2,4,5-triphenyl-1H-imidazole

Base Information

• Chemical Name: 1-Methyl-2,4,5-triphenyl-1H-imidazole
• CAS No.: 22397-44-0
• Molecular Formula: C22H18N2
• Molecular Weight: 310.398
• DSSTox Substance ID: DTXSID40505524
• Nikkaji Number: J570.170H
• Wikidata: Q82360721
• Mol file: 22397-44-0.mol

Synonyms:1-Methyl-2,4,5-triphenyl-1H-imidazole;22397-44-0;SCHEMBL822678;DTXSID40505524

Chemical Property of 1-Methyl-2,4,5-triphenyl-1H-imidazole

Chemical Property:

• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 310.146998583
• Heavy Atom Count: 24
• Complexity: 377

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C(=C(N=C1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

Technology Process of 1-Methyl-2,4,5-triphenyl-1H-imidazole

There total 25 articles about 1-Methyl-2,4,5-triphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1R,5S)-4-Methyl-1,3,5,7,7-pentaphenyl-6-oxa-2,4-diaza-bicyclo[3.2.0]hept-2-ene (108099-97-4) → benzophenone (119-61-9) + 1-methyl-2,4,5-triphenyl-1H-imidazole (22397-44-0)

Guidance literature:

In various solvent(s); at 120 ℃; for 2.5h; Thermodynamic data; cycloreversion of further oxetane derivatives;

DOI:10.1016/S0040-4039(00)94787-7

Reference yield: 96.0%

N-Methyl-N-<2-<<(methylamino)phenylmethylene>amino>-1,2-diphenylethenyl>benzamide → 1-methyl-2,4,5-triphenyl-1H-imidazole (22397-44-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating;

DOI:10.1021/jo00077a033

Reference yield: 91.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + benzonitrile (100-47-0) + methylamine (74-89-5) → 1-methyl-2,4,5-triphenyl-1H-imidazole (22397-44-0)

Guidance literature:

With trifluoroacetic acid; In glycerol; at 120 ℃; for 0.166667h; Microwave irradiation; Sealed tube; Green chemistry;

DOI:10.1039/c6ra11171h

upstream raw materials:

diazomethane

lophine

N-desyl-N-methylbenzamide

2-(Benzyl-methyl-hydrazono)-1,2-diphenyl-ethanone

Downstream raw materials:

C₂₂H₁₈N₂O₂

1-methyl-2-ohenyl-1H-phenanthro<9,10-d>imidazole

(1R,5S)-4-Methyl-1,3,5-triphenyl-7,7-di-p-tolyl-6-oxa-2,4-diaza-bicyclo[3.2.0]hept-2-ene

Refernces

• 1、 Angyal, Anikó,Demjén, András,W?lfling, János,Puskás, László G.,Kanizsai, Iván. "Acid-Catalyzed 1,3-Dipolar Cycloaddition of 2 H-Azirines with Nitrones: An Unexpected Access to 1,2,4,5-Tetrasubstituted Imidazoles". . p. 3587 - 3595. Retrieved 2020/03/10.
• 2、 Esmaeilpour, Mohsen,Javidi, Jaber,Dehghani, Farzaneh,Zahmatkesh, Saeed. "One-pot synthesis of multisubstituted imidazoles catalyzed by Dendrimer-PWAn nanoparticles under solvent-free conditions and ultrasonic irradiation". . p. 163 - 185. Retrieved 2017/01/14.