Cyclohex-2-en-1-amine hydrochloride

Base Information

• Chemical Name: Cyclohex-2-en-1-amine hydrochloride
• CAS No.: 22613-33-8
• Molecular Formula: C6H11N.ClH
• Molecular Weight: 133.621
• European Community (EC) Number: 878-828-4
• DSSTox Substance ID: DTXSID00522257
• Mol file: 22613-33-8.mol

Synonyms:cyclohex-2-en-1-amine hydrochloride;22613-33-8;cyclohex-2-en-1-amine;hydrochloride;2-Cyclohexen-1-amine hydrochloride;Cyclohex-2-enamine hydrochloride;DTXSID00522257;cyclohex-2-en-1-aminehydrochloride;MFCD14635796;AKOS006339872;2-Cyclohexen-1-amine, hydrochloride (1:1);CS-0230930;D84435;EN300-106270;Cyclohex-2-en-1-amine--hydrogen chloride (1/1);F8888-4627;Z1203579654

Chemical Property of Cyclohex-2-en-1-amine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 133.0658271
• Heavy Atom Count: 8
• Complexity: 76.2

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC=CC(C1)N.Cl

Technology Process of Cyclohex-2-en-1-amine hydrochloride

There total 9 articles about Cyclohex-2-en-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexene (110-83-8) → 2-cyclohexenylamine hydrochloride (22613-33-8)

Guidance literature:

cyclohexene; With Benzophenone imine; iodobenzene dimethoxide; at 20 ℃; for 24h; Inert atmosphere; Irradiation;

With hydrogenchloride; In methanol; water; at 10 ℃; for 24h; Inert atmosphere; Irradiation;

DOI:10.1002/chem.202102627

Reference yield: 70.0%

N-cyclohex-2-enyl-4-methyl-benzenesulfonamide (57981-18-7) → 2-cyclohexenylamine hydrochloride (22613-33-8)

Guidance literature:

With naphthalene; sodium; In 1,2-dimethoxyethane; for 1h; Ambient temperature;

DOI:10.1246/bcsj.62.1167

Reference yield: 64.0%

3-azido-1-cyclohexene (16717-84-3) → 2-cyclohexenylamine hydrochloride (22613-33-8)

Guidance literature:

3-azido-1-cyclohexene; With lithium aluminium tetrahydride; In diethyl ether; Heating;

With hydrogenchloride; In diethyl ether;

DOI:10.1002/adsc.200404372

upstream raw materials:

rac-3-acetoxycyclohexene

N-cyclohex-2-enyl-4-methyl-benzenesulfonamide

3-azido-1-cyclohexene

rac-3-bromocyclohexene

Downstream raw materials:

benzyl (RS)-cyclohex-2-en-1-ylcarbamate

N-(cyclohex-2-en-1-yl)pivalamide

optically inactive bis-(cis-2-benzoylamino-cyclohexyl)-disulfide

(+/-)-N-(trans-2-mercapto-cyclohexyl)-benzamide

Refernces

• 1、 Merten, Sandra,Froehlich, Roland,Kataeva, Olga,Metz, Peter. "Synthesis of sultams by intramolecular Heck reaction". . p. 754 - 758. Retrieved 2007/10/03.
• 2、 Tsushima, Susumu,Yamada, Yasuhiro,Onami, Tetsuo,Oshima, Koichiro,Chaney, Michael O.,et all.. "An Efficient Route to Both Enantiomers of N-(p-Tolylsulfonyl)-benzenesulfonimidamide and Their Use for Asymmetric Allylic Amination of Olefins". . p. 1167 - 1178. Retrieved 2007/10/02.