bicyclo[2.2.2]octane1,4diaMine dihydrochloride

Base Information

• Chemical Name: bicyclo[2.2.2]octane1,4diaMine dihydrochloride
• CAS No.: 2277-93-2
• Molecular Formula: C8H16N2.2ClH
• Molecular Weight: 213.14800
• Mol file: 2277-93-2.mol

Synonyms:

Chemical Property of bicyclo[2.2.2]octane1,4diaMine dihydrochloride

Chemical Property:

• Melting Point: >310 °C
• PSA: 52.04000
• LogP: 3.75380

Purity/Quality:

98%,99%, ^*data from raw suppliers

bicyclo[2.2.2]octane-1,4-diamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of bicyclo[2.2.2]octane1,4diaMine dihydrochloride

There total 2 articles about bicyclo[2.2.2]octane1,4diaMine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

bicyclo<2.2.2>octane-1,4-dicarboxylic acid (711-02-4) → 1,4-diaminobicyclo[2.2.2]octane dihydrochloride (2277-93-2)

Guidance literature:

bicyclo<2.2.2>octane-1,4-dicarboxylic acid; With diphenylphosphoranyl azide; triethylamine; In toluene; at 20 - 90 ℃; for 3h;

With hydrogenchloride; In water; at 0 - 20 ℃; for 3h;

Reference yield:

bicyclo[2.2.2] octane-1,4-diamine (1659-77-4) → bicyclo [2.2.2]octane-1,4-diamine dihydrochloride (2277-93-2)

Guidance literature:

With hydrogenchloride; In water; at 0 - 20 ℃; for 3h;

Reference yield: 86.0%

bicyclo [2.2.2]octane-1,4-diamine dihydrochloride (2277-93-2) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl N-(1-amino-4-bicyclo[2.2.2]octanyl)carbamate (1630906-54-5)

Guidance literature:

bicyclo [2.2.2]octane-1,4-diamine dihydrochloride; With sodium hydroxide; In methanol; water; for 0.25h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at 20 ℃; for 17h;

upstream raw materials:

bicyclo<2.2.2>octane-1,4-dicarboxylic acid

bicyclo[2.2.2] octane-1,4-diamine

Downstream raw materials:

tert-butyl N-(1-amino-4-bicyclo[2.2.2]octanyl)carbamate

Refernces

• 1、 -. "PEPTIDASE INHIBITORS". Page/Page column 34. . Retrieved 2010/10/19.