Isoquinoline, 1-(2-methylphenyl)-

Base Information

• Chemical Name: Isoquinoline, 1-(2-methylphenyl)-
• CAS No.: 22826-52-4
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol file: 22826-52-4.mol

Synonyms:

Chemical Property of Isoquinoline, 1-(2-methylphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoquinoline, 1-(2-methylphenyl)-

There total 11 articles about Isoquinoline, 1-(2-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

o-tolyltris(2-propoxy)titanium (676270-02-3) + 1-chloroisoquinoline (19493-44-8) → 1-(2-methylphenyl)-isoquinoline (22826-52-4)

Guidance literature:

o-tolyltris(2-propoxy)titanium; With N-methyl-2-phenyl-3-(dicyclohexylphosphino)-1H-indole; palladium diacetate; In toluene; for 0.0833333h; Inert atmosphere;

1-chloroisoquinoline; In toluene; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1002/anie.200904033

Reference yield: 92.0%

2-Methylphenylboronic acid (16419-60-6) + 1-chloroisoquinoline (19493-44-8) → 1-(2-methylphenyl)-isoquinoline (22826-52-4)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; In water; at 60 ℃; for 8h;

DOI:10.1039/c0gc00251h

Reference yield: 87.0%

1-iodoisoquiniline (19658-77-6) + 2-methylphenylzinc chloride (84109-17-1) → 1-(2-methylphenyl)-isoquinoline (22826-52-4)

Guidance literature:

With copper(l) iodide; lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201502379

upstream raw materials:

o-tolyltris(2-propoxy)titanium

1-chloroisoquinoline

2-Methylphenylboronic acid

ortho-tolylmagnesium bromide

Downstream raw materials:

C₄₄H₃₁N

Refernces

• 1、 -. "Red light metal complex, preparation method and application thereof". Paragraph 0086-0088. . Retrieved 2019/01/15.
• 2、 Zhang, Jing,Chen, Jie,Zhang, Xiaoyun,Lei, Xiaoguang. "Total syntheses of menisporphine and daurioxoisoporphine c enabled by photoredox-catalyzed direct C-H arylation of isoquinoline with aryldiazonium Salt". . p. 10682 - 10688. Retrieved 2015/02/19.