1-Methylcyclopropanamine

Base Information

• Chemical Name: 1-Methylcyclopropanamine
• CAS No.: 22936-83-0
• Molecular Formula: C4H9N
• Molecular Weight: 71.1222
• Hs Code.: 2921300090
• European Community (EC) Number: 815-392-6
• DSSTox Substance ID: DTXSID80469999
• Nikkaji Number: J930.805I
• Wikidata: Q72489785
• Mol file: 22936-83-0.mol

Synonyms:1-METHYLCYCLOPROPANAMINE;22936-83-0;1-methylcyclopropan-1-amine;Cyclopropanamine, 1-methyl-;1-methyl-cyclopropylamine;(1-METHYLCYCLOPROPYL)AMINE;1-methylcyclopropylamine;1-METHYL-1-CYCLOPROPANAMINE;amino-methyl-cyclopropane;1-Methyl-cyclopropanamine;DTXSID80469999;VSRXAWSAKJABKW-UHFFFAOYSA-N;MFCD11007844;AKOS005173913;SB35625;A4869;BB 0257898;FT-0683150;EN300-66135;W10114

Chemical Property of 1-Methylcyclopropanamine

Chemical Property:

• Vapor Pressure: 189.47mmHg at 25°C
• Melting Point: 61℃
• Refractive Index: 1.4130
• Boiling Point: 60.895 °C at 760 mmHg
• PKA: 9.10±0.20(Predicted)
• Flash Point: -30.459 °C
• PSA: 26.02000
• Density: 0.898g/cm³
• LogP: 1.19790
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 71.073499291
• Heavy Atom Count: 5
• Complexity: 45.6

Purity/Quality:

99%, ^*data from raw suppliers

1-METHYL-1-CYCLOPROPANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC1)N

Technology Process of 1-Methylcyclopropanamine

There total 1 articles about 1-Methylcyclopropanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylcyclopropylamine hydrochloride (88887-87-0) → (1-methylcyclopropyl)amine (22936-83-0)

Guidance literature:

With potassium hydroxide;

Reference yield: 85.0%

(1-methylcyclopropyl)amine (22936-83-0) + 2-amino-N-tert-butoxycarbonyl-5-chlorobenzaldehyde (260559-52-2) → tert-butyl (4-chloro-2-(((1-methylcyclopropyl)-amino)methyl)phenyl)-carbamate

Guidance literature:

(1-methylcyclopropyl)amine; 2-amino-N-tert-butoxycarbonyl-5-chlorobenzaldehyde; In methanol; at 43 ℃; for 16h;

With methanol; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 20h;

Reference yield: 63.0%

2-fluoro-6-{2-[(4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl]ethyl}benzoic acid (1352240-35-7) + (1-methylcyclopropyl)amine (22936-83-0) → 2-{2-[(4aS,5R)-1-(4-fluorophenyl)-5-hydroxy-4a-methyl-1,4,4a,5,6,7-hexahydrocyclopenta[f]indazol-5-yl]ethyl}-N-(1-methylcyclopropyl)benzamide (1021537-49-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2011.10.054

upstream raw materials:

1-methylcyclopropylamine hydrochloride

Downstream raw materials:

(Z)-2-(2,4-Dichloro-5-fluoro-benzoyl)-3-(1-methyl-cyclopropylamino)-acrylic acid ethyl ester

ethene

1-Hydroxy-3-butanone

acetonitrile

Refernces