2-Propenamide, 3-(4-chlorophenyl)-N,N-diethyl-

Base Information

• Chemical Name: 2-Propenamide, 3-(4-chlorophenyl)-N,N-diethyl-
• CAS No.: 23784-71-6
• Molecular Formula: C13H16ClNO
• Molecular Weight: 237.729
• Mol file: 23784-71-6.mol

Synonyms:

Chemical Property of 2-Propenamide, 3-(4-chlorophenyl)-N,N-diethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenamide, 3-(4-chlorophenyl)-N,N-diethyl-

There total 4 articles about 2-Propenamide, 3-(4-chlorophenyl)-N,N-diethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-[3-(4-chloro-phenyl)-acryloyl]-1H-benzotriazole (57710-83-5) + diethylamine (109-89-7) → 4-Chlor-zimtsaeure-N,N-diethylamid (23784-71-6)

Guidance literature:

With samarium (III) iodide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1080/00397910802431180

Reference yield: 57.0%

4-n-chlorophenylacetylene (873-73-4) + carbon monoxide (201230-82-2) + diethylamine (109-89-7) → 4-Chlor-zimtsaeure-N,N-diethylamid (23784-71-6) + 2-(4-chlorophenyl)-N,N-diethylacrylamide (137958-84-0)

Guidance literature:

With triphenylphosphine; methyl iodide; bis-triphenylphosphine-palladium(II) chloride; at 120 ℃; for 6h; under 3800 Torr; Title compound not separated from byproducts;

DOI:10.1246/cl.1991.1673

Reference yield:

p-chlorocinnamic acid (1615-02-7,940-62-5) + diethylamine (109-89-7) → 4-Chlor-zimtsaeure-N,N-diethylamid (23784-71-6)

Guidance literature:

p-chlorocinnamic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3.5h;

diethylamine; With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/ol502834g

upstream raw materials:

4-n-chlorophenylacetylene

carbon monoxide

diethylamine

1-[3-(4-chloro-phenyl)-acryloyl]-1H-benzotriazole

Downstream raw materials:

4-chloro-N,N-diethyl-α-oxo-benzeneacetamide

Refernces

• 1、 Wang, Xiaoxia,He, Liang,Li, Zhifang,Wang, Wencun,Liu, Junhua. "SmI3-catalyzed addition of amines to α,β-unsaturated N-acylbenzotriazoles". experimental part. p. 819 - 829. Retrieved 2009/08/08.