Ethenesulfonamide

Base Information

• Chemical Name: Ethenesulfonamide
• CAS No.: 2386-58-5
• Molecular Formula: C2H5NO2S
• Molecular Weight: 107.133
• Hs Code.: 2935009090
• Mol file: 2386-58-5.mol

Synonyms:ethylenesulfonic acid amide;ethenesulphonamide;Ethylenesulfonamide;Vinylsulfonamide;Aethensulfonsaeure-amid;ethenesulfonic acid amide;

Chemical Property of Ethenesulfonamide

Chemical Property:

• Melting Point: 24 °C
• Boiling Point: 114 °C(Press: 0.1 Torr)
• PKA: 9.76±0.60(Predicted)
• PSA: 68.54000
• Density: 1.316±0.06 g/cm3(Predicted)
• LogP: 1.19950

Purity/Quality:

98% ^*data from raw suppliers

ETHENE SULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethenesulfonamide

There total 11 articles about Ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

methyl 4-{2-[2-(2-aminoethyl)-1-benzhydryl-5-chloro-1H-indol-3-yl]ethoxy}benzoate amine (540522-69-8) + 4-[2-(1-benzhydryl-2-{2-[(benzylsulfonyl)amino]ethyl}-5-chloro-1H-indol-3-yl)ethoxy]benzoic acid (540522-85-8) + 2-Chloroethanesulfonyl chloride (1622-32-8) → vinyl sulfonamide (2386-58-5)

Guidance literature:

With triethylamine; In tetrahydrofuran;

Reference yield: 70.0%

2-(trifluoromethoxy)ethane-1-sulfonyl chloride → vinyl sulfonamide (2386-58-5)

Guidance literature:

With ammonia; at -33 ℃; under 760.051 Torr; Reagent/catalyst; Temperature;

DOI:10.1016/j.jfluchem.2021.109799

Reference yield: 60.0%

2-Chloroethanesulfonyl chloride (1622-32-8) → vinyl sulfonamide (2386-58-5)

Guidance literature:

With ammonia; In ethyl acetate; at 20 ℃;

upstream raw materials:

2-Chloroethanesulfonyl chloride

diethyl ether

ethane-1,2-disulfonyl chloride

ammonia

Downstream raw materials:

2-phenylsulfanyl-ethanesulfonic acid amide

1,4-Diphenyl-2-sulfamoyl-naphthalin

cyclohexyl-(1,1-dioxo-5,6-dihydro-1H-1λ⁶-[1,4,2]dithiazin-3-yl)-amine

(E)-(2-phenylethenyl)sulfonamide

Refernces

• 1、 Bonnar, James,Dixon, Ian,Evison, Benny J.,Kelly, Graham E.,Kumar, Sanjay,Lambert, Gilles,Nativel, Brice,Palmer, James T.,Parmar, Jasneet,Rathi, Anuj Kumar,Suchowerska, Alexandra K.,Tang, Wei,Teng, Yanfen,Treutlein, Herbert,Wang, Jie,Xu, Yanfeng,Zeng, Jun,Zhu, Qing,Chemello, Kévin. "A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove". supporting information. . Retrieved 2020/02/13.
• 2、 -. "ISOXAZOLE CARBOXAMIDE COMPOUNDS AND USES THEREOF". Page/Page column 66-67. . Retrieved 2020/04/25.