(Benzylmethylamino)acetone

Base Information

• Chemical Name: (Benzylmethylamino)acetone
• CAS No.: 23982-57-2
• Molecular Formula: C11H15NO
• Molecular Weight: 177.246
• Hs Code.: 2922399090
• Mol file: 23982-57-2.mol

Synonyms:1-[benzyl(methyl)amino]acetone;(Benzyl-methyl-amino)-aceton;2-Propanone, 1-[methyl(phenylmethyl)amino]-;1-(N-benzyl-N-methylamino)-2-propanone;1-[methyl(phenylmethyl)amino]-2-propanone;

Chemical Property of (Benzylmethylamino)acetone

Chemical Property:

• PSA: 20.31000
• LogP: 1.70740

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (Benzylmethylamino)acetone

There total 10 articles about (Benzylmethylamino)acetone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

chloroacetone (78-95-5) + benzyl-methyl-amine (103-67-3) → 1-(benzyl(methyl)amino)propan-2-one (23982-57-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 16 - 30 ℃; for 19h; Large scale;

Reference yield: 90.0%

2-(Trimethylsilyloxy)propene (1833-53-0) + benzyl-methyl-amine (103-67-3) → 1-(benzyl(methyl)amino)propan-2-one (23982-57-2)

Guidance literature:

With lithium perchlorate; sodium iodide; In acetonitrile; Electrochemical reaction;

DOI:10.1021/acs.orglett.0c02068

Reference yield: 84.1%

tert-butyl methyl ether (1634-04-4) + chloroacetone (78-95-5) + benzyl-methyl-amine (103-67-3) → 1-(benzyl(methyl)amino)propan-2-one (23982-57-2)

Guidance literature:

upstream raw materials:

benzyl-methyl-amine

1-bromoacetone

ethyl N-methyl-N-(phenylmethyl)glycine

bis(trimethylstannyl)methane

Downstream raw materials:

1-(tert-butoxycarbonyl(methyl)amino)propan-2-one

1-(N-benzyl-N-methylamino)-2-propyl alcohol

C₁₅H₂₃O₃N

1-(benzyl-methyl-amino)-2-[1-(2-diethylamino-ethyl)-indol-2-yl]-propan-2-ol

Refernces

• 1、 Strehl, Julia,Hilt, Gerhard. "Electrochemical, Iodine-Mediated α-CH Amination of Ketones by Umpolung of Silyl Enol Ethers". supporting information. p. 5968 - 5972. Retrieved 2020/08/12.
• 2、 -. "Novel, Acyclically Substituted Furopyrimidine Derivatives and Use Thereof". Page/Page column 32. . Retrieved 2009/12/28.