5-Chloro-2,4,6-triMethylpyriMidine

Base Information

• Chemical Name: 5-Chloro-2,4,6-triMethylpyriMidine
• CAS No.: 24307-72-0
• Molecular Formula: C7H9ClN2
• Molecular Weight: 156.61300
• Hs Code.: 2933599090
• Mol file: 24307-72-0.mol

Synonyms:5-chloro-2,4,6-trimethyl-pyrimidine;5-Chlor-2,4,6-trimethylpyrimidin;

Chemical Property of 5-Chloro-2,4,6-triMethylpyriMidine

Chemical Property:

• PSA: 25.78000
• LogP: 2.05520
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

5-Chloro-2,4,6-trimethylpyrimidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Chloro-2,4,6-triMethylpyriMidine

There total 5 articles about 5-Chloro-2,4,6-triMethylpyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloroacetone (78-95-5) + acetonitrile (75-05-8,26809-02-9) → 5-Chlor-2,4,6-trimethylpyrimidin (24307-72-0)

Guidance literature:

With trifluoromethylsulfonic anhydride; In dichloromethane; for 24h; Ambient temperature; other nitriles ans α-halomethyl ketones;

DOI:10.1055/s-1992-26296

Reference yield:

2,4,5-trimethyl-1H-imidazole (822-90-2) + 1,1,1,3,3,3-hexachloro-propan-2-one (116-16-5) → 2-chloro-3,5,6-trimethylpyrazine (68303-35-5) + 4-chloro-2,5,6-trimethylpyrimidine (34916-70-6) + 5-Chlor-2,4,6-trimethylpyrimidin (24307-72-0)

Guidance literature:

With sodium methylate; In diethyl ether; dichloromethane; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1039/P19800001427

Reference yield:

2,4,5-trimethyl-1H-imidazole (822-90-2) + sodium trichloroacetate (650-51-1) → 2-chloro-3,5,6-trimethylpyrazine (68303-35-5) + 5-Chlor-2,4,6-trimethylpyrimidin (24307-72-0)

Guidance literature:

In 1,2-dimethoxyethane; for 22h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1039/P19800001427

upstream raw materials:

2,4,5-trimethyl-1H-imidazole

1,1,1,3,3,3-hexachloro-propan-2-one

chloroform

sodium trichloroacetate

Refernces

• 1、 Busby, Reginald E.,Khan, Mohammad A.,Khan, Mohammad R.,Parrick, John,Shaw, C. J. Granville,Iqbal, Mohammad. "Reactions of Halogenomethanes in the Vapor Phase. Part 4. The Reactions of Imidazoles with Chloroform at 550 deg C, and a Comparison with their Liquid-phase Reactions with Trichloroacetate Ion or Hexachloroacetone and Base". . p. 1427 - 1430. Retrieved 2007/10/02.