ETHYL (4-BROMOANILINO)(OXO)ACETATE

Base Information

• Chemical Name: ETHYL (4-BROMOANILINO)(OXO)ACETATE
• CAS No.: 24451-15-8
• Molecular Formula: C10H10BrNO3
• Molecular Weight: 272.098
• Hs Code.: 2924299090
• Mol file: 24451-15-8.mol

Synonyms:(4-Brom-phenyl)-oxalamidsaeure-aethylester;Nonadecansaeure-aethylester;Pendadecanal;ethyl 4'-bromooxanilate;Nonadecansaeureethylester;4-Brom-oxanilsaeure-aethylester;n-Nonadecansaeureethylester;Ethylnonadecanoat;Oxalsaeure-aethylester-(4-brom-anilid);Nonadecanoic acid,ethyl ester;(4-bromo-phenyl)-oxalamic acid ethyl ester;Ethyl-n-nonadecanoat;ethyl N-p-bromophenyloxamate;ethyl 2-(4-bromophenylamino)-2-oxoacetate;

Chemical Property of ETHYL (4-BROMOANILINO)(OXO)ACETATE

Chemical Property:

• PSA: 58.89000
• LogP: 2.60020
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

≥95% ^*data from raw suppliers

ethyl2-(4-bromophenylamino)-2-oxoacetate ≥98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL (4-BROMOANILINO)(OXO)ACETATE

There total 9 articles about ETHYL (4-BROMOANILINO)(OXO)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl oxalyl chloride (4755-77-5) + 4-bromo-aniline (106-40-1) → ethyl N-p-bromophenyloxamate (24451-15-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.ica.2016.01.002

Reference yield: 77.0%

glyoxylic acid ethyl ester (924-44-7) + 4-bromo-aniline (106-40-1) → ethyl N-p-bromophenyloxamate (24451-15-8)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 80 ℃; for 6h;

DOI:10.1039/c5ra17425b

Reference yield: 76.0%

oxalic acid diethyl ester (95-92-1) + 4-bromo-aniline (106-40-1) → ethyl N-p-bromophenyloxamate (24451-15-8)

Guidance literature:

In neat (no solvent); at 100 ℃; for 27h;

upstream raw materials:

Ethyl oxanilate

oxalic acid diethyl ester

4-bromo-aniline

Ethyl oxalyl chloride

Downstream raw materials:

N-(5-amino-[1,3,4]thiadiazole-2-sulfonyl)-N'-(4-bromo-phenyl)-oxalamide

N'-<4-Diethylamino-1-methyl-butyl>-N-<4-brom-phenyl>-oxamid jodmethylat

4-bromooxanilic acid

C₂₀H₁₉BrN₄OS

Refernces

• 1、 Bakare, Safyah B.. "SYNTHESIS of NOVEL NITROGEN HETEROCYCLES BEARING BIOLOGICAL ACTIVE CARBOXAMIDE MOIETY AS POTENTIAL ANTITUMOR AGENTS". . p. 449 - 459. Retrieved 2022/01/03.
• 2、 -. "NOVEL HETEROARYL COMPOUND, ENANTIOMER, DIASTEREOMER OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT". Paragraph 0823; 0824. . Retrieved 2020/02/14.