D-METHIONINE METHYL ESTER

Base Information

• Chemical Name: D-METHIONINE METHYL ESTER
• CAS No.: 21691-49-6
• Molecular Formula: C6H13NO2S
• Molecular Weight: 163.241
• Hs Code.: 2930909090
• Mol file: 21691-49-6.mol

Synonyms:Methionine,methyl ester, D- (8CI);(R)-Methionine methyl ester;NSC 522628;O-Methyl-D-methionine;

Chemical Property of D-METHIONINE METHYL ESTER

Chemical Property:

• Boiling Point: 240 °C at 760 mmHg
• Flash Point: 99 °C
• PSA: 77.62000
• Density: 1.094g/cm³
• LogP: 0.94010

Purity/Quality:

99% ^*data from raw suppliers

D-METHIONINE METHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-METHIONINE METHYL ESTER

There total 9 articles about D-METHIONINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

D-methionine (348-67-4,26062-47-5,58576-49-1) + 2,2-dimethoxy-propane (77-76-9) → D-methionine methyl ester (21691-49-6,874219-77-9)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 36h;

DOI:10.1039/b212270g

Reference yield:

DL-methionine methyl ester (10332-17-9,874219-77-9) → D-methionine (348-67-4,26062-47-5,58576-49-1) + L-methionine (63-68-3,26062-47-5,58576-49-1) + D-methionine methyl ester (21691-49-6,874219-77-9) + Met-OMe (10332-17-9,874219-77-9)

Guidance literature:

With Bacillus licheniformis; sodium hydrogencarbonate; 1-ethyl-3-methylimidazolium acetate; In water; water-d2; at 30 ℃; for 0.33h;

DOI:10.1016/j.tetasy.2006.09.009

Reference yield:

D-methionine (348-67-4,26062-47-5,58576-49-1) + methyl iodide (74-88-4) → D-methionine methyl ester (21691-49-6,874219-77-9)

Guidance literature:

In methanol; water; at 30 ℃; for 24h;

DOI:10.1021/jo5023712

upstream raw materials:

methanol

D-methionine

DL-methionine methyl ester

L-Tartaric acid

Downstream raw materials:

(S)-3-Benzyloxycarbonylamino-N-((R)-1-methoxycarbonyl-3-methylsulfanyl-propyl)-succinamic acid benzyl ester

N-9-fluorenylmethyloxycarbonyl-DL-3,3-difluoro-phenylalanyl-L-methionyl methyl ester

methyl (2R)-2-(benzyloxycarbonylamino)-4-methylthiobutyrate

N-acetyl-D-methionine

Refernces

• 1、 Zhao, Hua,Jackson, Lee,Song, Zhiyan,Olubajo, Olarongbe. "Using ionic liquid [EMIM][CH3COO] as an enzyme-'friendly' co-solvent for resolution of amino acids". . p. 2491 - 2498. Retrieved 2007/10/03.
• 2、 Hanessian,Bouzbouz,Boudon,Tucker,Peyroulan. "Picking the S1, S1' and S2' pockets of matrix metalloproteinases. A niche for potent acyclic sulfonamide inhibitors.". . p. 1691 - 1696. Retrieved 2007/10/03.