Propyl(4-methylphenyl) sulfide

Base Information

• Chemical Name: Propyl(4-methylphenyl) sulfide
• CAS No.: 24599-52-8
• Molecular Formula: C10H14S
• Molecular Weight: 166.287
• Hs Code.: 2930909090
• Mol file: 24599-52-8.mol

Synonyms:Sulfide,propyl p-tolyl;1-Methyl-4-(propylsulfanyl)benzene;Benzene,1-methyl-4-(propylthio);Propyl p-tolyl sulfide;

Chemical Property of Propyl(4-methylphenyl) sulfide

Chemical Property:

• Boiling Point: 234-235 °C
• PSA: 25.30000
• Density: 0.9755 g/cm3
• LogP: 3.49710

Purity/Quality:

PROPYL P-TOLYL SULFIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propyl(4-methylphenyl) sulfide

There total 19 articles about Propyl(4-methylphenyl) sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-propyl-2'-thiopyridine (26891-63-4) + (4-Methylphenyl)-pivaloat (69120-23-6) → 4-methylphenyl propyl sulfide (24599-52-8)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 3,4-thiene-2,3-diylbis(dicyclohexylphosphine); zinc; In toluene; at 150 ℃; for 24h; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1021/jacs.1c04215

Reference yield: 92.0%

→ 4-methylphenyl propyl sulfide (24599-52-8)

Guidance literature:

Reference yield: 72.0%

3-[(4-methylphenyl)sulfanyl]-1-propanol (3147-28-2) → di(p-tolyl) disulfide (103-19-5) + 4-methylphenyl propyl sulfide (24599-52-8) + para-thiocresol (106-45-6)

Guidance literature:

PPA; In carbon disulfide; for 40h; Ambient temperature;

upstream raw materials:

propyl bromide

para-thiocresol

1-Chloropropane

3-[(4-methylphenyl)sulfanyl]-1-propanol

Downstream raw materials:

1,1,2-trifluoro-2-(p-methylphenylthio)propane

p-tolyl propyl sulfoxide

1-(4-tolylsulfonyl)propane

phenyl p-methylbenzoate

Refernces

• 1、 Isshiki, Ryota,Kurosawa, Miki B.,Muto, Kei,Yamaguchi, Junichiro. "Ni-Catalyzed Aryl Sulfide Synthesis through an Aryl Exchange Reaction". supporting information. p. 10333 - 10340. Retrieved 2021/07/21.
• 2、 Crosignani, Stefano,Prêtre, Adeline,Jorand-Lebrun, Catherine,Fraboulet, Ga?le,Seenisamy, Jeyaprakashnarayanan,Augustine, John Kallikat,Missotten, Marc,Humbert, Yves,Cleva, Christophe,Abla, Nada,Daff, Hamina,Schott, Olivier,Schneider, Manfred,Burgat-Charvillon, Fabienne,Rivron, Delphine,Hamernig, Ingrid,Arrighi, Jean-Fran?ois,Gaudet, Marilène,Zimmerli, Simone C.,Juillard, Pierre,Johnson, Zoe. "Discovery of potent, selective, and orally bioavailable alkynylphenoxyacetic acid CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases". experimental part. p. 7299 - 7317. Retrieved 2011/12/15.