2-(4-METHYLPHENYL)QUINOLINE

Base Information

• Chemical Name: 2-(4-METHYLPHENYL)QUINOLINE
• CAS No.: 24667-94-5
• Molecular Formula: C16H13N
• Molecular Weight: 219.286
• Mol file: 24667-94-5.mol

Synonyms:2-(4-4-methylphenyl)quinoline;2-p-Tolyl-quinoline;2-(4'-methylphenyl)quinoline;2-(4-methylphenyl)-quinoline;2-(p-methylphenyl)quinoline;2-(p-tolyl)quinoline;2-(4-tolyl)quinoline;

Chemical Property of 2-(4-METHYLPHENYL)QUINOLINE

Chemical Property:

• Melting Point: 81 - 82 °C (ethyl acetate)
• PSA: 12.89000
• LogP: 4.21020

Purity/Quality:

99% ^*data from raw suppliers

2-(P-TOLYL)QUINOLINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-METHYLPHENYL)QUINOLINE

There total 92 articles about 2-(4-METHYLPHENYL)QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2,3,4-tetrahydro-2-(4-methylphenyl)quinoline (123612-59-9) → 2-(4-methylphenyl)quinoline (24667-94-5)

Guidance literature:

With tris(pentafluorophenyl)borate; In para-xylene; at 150 ℃; for 22h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201606177

Reference yield: 99.0%

2-Aminobenzyl alcohol (5344-90-1) + para-methylacetophenone (122-00-9) → 2-(4-methylphenyl)quinoline (24667-94-5)

Guidance literature:

With benzophenone; potassium tert-butylate; In 1,4-dioxane; at 90 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo801678n

Reference yield: 99.0%

(E)-3-(2-aminophenyl)-1-(p-tolyl)prop-2-en-1-one → 2-(4-methylphenyl)quinoline (24667-94-5)

Guidance literature:

In tetrahydrofuran; for 14h; Irradiation;

DOI:10.1039/c7ob00558j

upstream raw materials:

quinoline

p-tolyllithium

2-p-tolyl-Cinchoninic acid

4-methyl-benzaldehyde

Downstream raw materials:

2-(4-diacetoxymethyl-phenyl)-quinoline

4-(quinolin-2-yl)benzaldehyde

1,2,3,4-tetrahydro-2-(4-methylphenyl)quinoline

4-[2]quinolyl-benzoic acid

Refernces

• 1、 Mondal, Rakesh,Chakraborty, Gargi,Guin, Amit Kumar,Pal, Subhasree,Paul, Nanda D.. "Iron catalyzed metal-ligand cooperative approaches towards sustainable synthesis of quinolines and quinazolin-4(3H)-ones". . . Retrieved 2021/10/12.
• 2、 -. "Ruthenium complex and preparation method thereof and catalytic application". Paragraph 0104-0106; 0109-0110. . Retrieved 2021/01/24.