1-(4-Fluorophenyl)-2-Methoxyethanone

Base Information

• Chemical Name: 1-(4-Fluorophenyl)-2-Methoxyethanone
• CAS No.: 247179-37-9
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 2914700090
• Mol file: 247179-37-9.mol

Synonyms:

Chemical Property of 1-(4-Fluorophenyl)-2-Methoxyethanone

Chemical Property:

• PSA: 26.30000
• LogP: 1.65480

Purity/Quality:

95% ^*data from raw suppliers

1-(4-Fluorophenyl)-2-methoxyethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-Fluorophenyl)-2-Methoxyethanone

There total 10 articles about 1-(4-Fluorophenyl)-2-Methoxyethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

methanol (67-56-1) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1-(4-fluorophenyl)-2-methoxyethan-1-one (247179-37-9)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid hydrazide; In water; at 20 ℃; for 16h; Schlenk technique;

DOI:10.1002/ejoc.201600723

Reference yield: 89.0%

((1-(4-fluorophenyl)vinyl)oxy)triisopropylsilane (1280738-13-7) + 4-cyano-1-methoxypyridin-1-ium tetrafluoroborate → 1-(4-fluorophenyl)-2-methoxyethan-1-one (247179-37-9)

Guidance literature:

With dipotassium hydrogenphosphate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; In acetonitrile; at 20 ℃; for 18h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.orglett.1c03444

Reference yield: 75.0%

4-fluorobenzonitrile (1194-02-1,143234-87-1) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → 4-(methoxymethyl)benzonitrile (1515-85-1) + 1-(4-fluorophenyl)-2-methoxyethan-1-one (247179-37-9)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With phenyllithium; In tetrahydrofuran; at 0 ℃; for 0.166667h;

4-fluorobenzonitrile; In tetrahydrofuran; at 20 ℃; for 2h;

With water; In tetrahydrofuran;

DOI:10.1055/s-1999-3580

upstream raw materials:

methanol

1-(4-fluorophenyl)ethanone

4-fluorobenzonitrile

(methoxymethyl)triphenylphosphonium chloride

Downstream raw materials:

3-(4-fluorophenyl)-3-oxopropionitrile

4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocyclooctane[b]pyridine-(1H)-ketone

(α-methoxy-4-fluorobenzyl)-(4-fluorophenyl)-ketone

Refernces

• 1、 -. "NOVEL THYROMIMETICS". Page/Page column 149. . Retrieved 2020/09/19.
• 2、 -. "METALLOENZYME INHIBITOR COMPOUNDS". Page/Page column 155. . Retrieved 2018/09/28.