2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride

Base Information

• Chemical Name: 2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride
• CAS No.: 24958-41-6
• Molecular Formula: C16H19NO.ClH
• Molecular Weight: 277.794
• Hs Code.: 2922199090
• DSSTox Substance ID: DTXSID10469164
• Mol file: 24958-41-6.mol

Synonyms:24958-41-6;2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride;N-methyl-2-(4-phenylmethoxyphenyl)ethanamine;hydrochloride;Benzeneethanamine, N-methyl-4-(phenylmethoxy)-, hydrochloride (1:1);2-(4-(benzyloxy)phenyl)-N-methylethan-1-amine hydrochloride;SCHEMBL4451835;DTXSID10469164;AM62630;O-Benzyl-N-methyltyramine hydrochloride;EN300-335904;{2-[4-(BENZYLOXY)PHENYL]ETHYL}(METHYL)AMINE HYDROCHLORIDE;2-[4-(Benzyloxy)phenyl]-N-methylethan-1-amine--hydrogen chloride (1/1)

Chemical Property of 2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 4.22040
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 277.1233420
• Heavy Atom Count: 19
• Complexity: 205

Purity/Quality:

98% ^*data from raw suppliers

2-(4-(Benzyloxy)phenyl)-N-methylethanaminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCC1=CC=C(C=C1)OCC2=CC=CC=C2.Cl

Technology Process of 2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride

There total 5 articles about 2-(4-(Benzyloxy)phenyl)-N-methylethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-t-butoxycarbonyl-N-methyl-O-benzyltyramine (788824-85-1) → N-methyl-O-benzyltyramine hydochloride (24958-41-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

DOI:10.1021/jm0505718

Reference yield:

N-(tert-butoxycarbonyl)-2-[4-(benzyloxy)phenyl]ethylamine (182921-01-3) → N-methyl-O-benzyltyramine hydochloride (24958-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 84 percent / dimethylformamide / 2.75 h / 0 - 20 °C

2.1: 89 percent / HCl / ethyl acetate / 20 °C

With hydrogenchloride; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0505718

Reference yield:

tyrosamine (51-67-2) → N-methyl-O-benzyltyramine hydochloride (24958-41-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 91 percent / aq. NaHCO₃ / tetrahydrofuran / 24 h

2.1: 58 percent / K₂CO₃ / dimethylformamide / 20 °C

3.1: NaH / dimethylformamide / 0 °C

3.2: 84 percent / dimethylformamide / 2.75 h / 0 - 20 °C

4.1: 89 percent / HCl / ethyl acetate / 20 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0505718

upstream raw materials:

N-t-butoxycarbonyl-N-methyl-O-benzyltyramine

N-(tert-butoxycarbonyl)-2-[4-(benzyloxy)phenyl]ethylamine

tyrosamine

N-t-butoxycarbonyl-tyramine

Downstream raw materials:

5-benzyloxy-N-[2-(4-benzyloxy-phenyl)-ethyl]-2-bromo-4-methoxy-N-methylbenzamide

[2-(4-benzyloxy-phenyl)-ethyl]methylamine

Refernces

• 1、 -. "Preparation of (-)-galantamine hydrobromide". Page/Page column 6-7. . Retrieved 2008/06/13.