Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate

Base Information

• Chemical Name: Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate
• CAS No.: 145643-75-0
• Molecular Formula: C₃₇H₆₁NO₇S
• Molecular Weight: 663.96
• Mol file: 145643-75-0.mol

Synonyms:

Chemical Property of Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate

There total 1 articles about Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + Orlistat (104872-04-0,104872-27-7,104872-28-8,111466-61-6,111466-62-7,111466-63-8,130193-40-7,130193-41-8,130193-42-9,130193-43-0,96829-58-2,1225451-00-2) + p-toluenesulfonyl chloride (98-59-9) → Methyl (2S,3S,5S)-5-<(S)-2-formamido-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate (145643-73-8) + Methyl (2S,3S,5S)-3-<(S)-2-formamido-4-methylpentanoyloxy>-2-hexyl-5-<(4-tolyl)sulfonyloxy>hexadecanoate (145643-74-9) + Methyl (2S,3S,5S)-5-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-3-<(4-tolyl)sulfonyloxy>hexadecanoate (145643-75-0) + Methyl (2S,3S,5S)-3-<(S)-2-isocyano-4-methylpentanoyloxy>-2-hexyl-5-<(4-tolyl)sulfonyloxy>hexadecanoate (145643-95-4)

Guidance literature:

With dmap; acetic acid; triethylamine; Yield given. Multistep reaction. Yields of byproduct given; 1.) 50 deg C, 4 d, 2.) CH₂Cl₂, r.t.;

DOI:10.1002/hlca.19920750513

upstream raw materials:

methanol

Orlistat

p-toluenesulfonyl chloride

Refernces