4-METHYLPHENOXYPROPIONITRILE 97

Base Information

• Chemical Name: 4-METHYLPHENOXYPROPIONITRILE 97
• CAS No.: 25268-01-3
• Molecular Formula: C10H11NO
• Molecular Weight: 161.203
• Hs Code.: 2926909090
• Mol file: 25268-01-3.mol

Synonyms:3-(P-TOLYLOXY)PROPANENITRILE;4-METHYLPHENOXYPROPIONITRILE;

Chemical Property of 4-METHYLPHENOXYPROPIONITRILE 97

Chemical Property:

• Melting Point: 44-48 °C(lit.)
• Boiling Point: 166 °C(Press: 20 Torr)
• Flash Point: >230?°F
• PSA: 33.02000
• Density: 1.032±0.06 g/cm3(Predicted)
• LogP: 2.28748

Purity/Quality:

97% ^*data from raw suppliers

3-(p-Tolyloxy)propanenitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLPHENOXYPROPIONITRILE 97

There total 4 articles about 4-METHYLPHENOXYPROPIONITRILE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

p-cresol (106-44-5) + acrylonitrile (107-13-1,25014-41-9) → 3-(4-methylphenoxy)propanenitrile (25268-01-3)

Guidance literature:

N-benzyl-trimethylammonium hydroxide; In methanol; for 8h; Heating;

Reference yield:

p-cresol (106-44-5) → 3-(4-methylphenoxy)propanenitrile (25268-01-3)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol (Triton B); acrylonitrile;

Reference yield:

sodium 4-methylphenoxide (1121-70-6) + acrylonitrile (107-13-1,25014-41-9) → 3-(4-methylphenoxy)propanenitrile (25268-01-3)

Guidance literature:

Multistep reaction;

upstream raw materials:

p-cresol

acrylonitrile

sodium 4-methylphenoxide

Downstream raw materials:

6-methylflavanone

3-(p-tolyloxy)propanoyl chloride

methyl 3-<(4-methylphenyl)oxy>propanoate

6-methyl-4-chromanone

Refernces

• 1、 Cho, Yang Yil,Jang, Hyu Jeong,Kim, Dong Hwan,Kim, Nam Yong,Kim, Nam-Jung,Kim, Young Min,Lee, Soo Jin,Lee, Yong Sup,Park, Boyoung Y.,Son, Seung Hwan,Yoo, Hyung-Seok. "Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids". supporting information. p. 10012 - 10023. Retrieved 2019/08/30.
• 2、 Iida, Hirokazu,Akatsu, Yusuke,Mizukami, Kazushi,Natori, Sho,Matsukawa, Minako,Takahashi, Kie. "Efficient and rapid synthesis of phenolic analogs of 4-phenylbutanoic acid using microwave-assisted Michael addition as a key reaction". supporting information. p. 581 - 585. Retrieved 2016/07/06.