Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester

Base Information

• Chemical Name: Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester
• CAS No.: 25445-76-5
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID90401249
• Mol file: 25445-76-5.mol

Synonyms:25445-76-5;Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester;ethyl N-(1-phenylethylideneamino)carbamate;DTXSID90401249;acetophenone ethoxycarbonylhydrazone

Chemical Property of Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester

Chemical Property:

• PSA: 54.18000
• LogP: 2.36110
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 206.105527694
• Heavy Atom Count: 15
• Complexity: 233

Purity/Quality:

ETHYL (ALPHA-METHYLBENZYLIDENE)CARBAZATE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)NN=C(C)C1=CC=CC=C1

Technology Process of Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester

There total 4 articles about Hydrazinecarboxylic acid, (1-phenylethylidene)-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetophenone (98-86-2) + ethylhydrazine carboxylate (4114-31-2) → N-ethoxycarbonyl-N'-(1-phenyl-ethylidene)-hydrazine (25445-76-5)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; Heating;

DOI:10.1016/0040-4039(95)01128-5

Reference yield: 60.0%

acetophenone (98-86-2) + ethylhydrazine carboxylate (4114-31-2) → acetophenone N-ethoxycarbonylhydrazone (25445-76-5)

Guidance literature:

With acetic acid; In ethanol; water; at 20 ℃; for 2h;

DOI:10.1021/jo052329e

Reference yield:

acetophenone (98-86-2) → N-ethoxycarbonyl-N'-(1-phenyl-ethylidene)-hydrazine (25445-76-5)

Guidance literature:

With ethanol; sodium carbonate;

DOI:10.1177/109442802237116

upstream raw materials:

acetophenone

ethylhydrazine carboxylate

Downstream raw materials:

4-phenyl-1,2,3-thiadiazole

4-phenyl-semicarbazide

1-ethoxycarbonyl-3,5-diphenyl pyrazole

methyl phenylethynyl sulfide

Refernces

• 1、 Dang, Tuan Thanh,Albrecht, Uwe,Gerwien, Katrin,Siebert, Melanie,Langer, Peter. "One-pot cyclizations of dilithiated oximes and hydrazones with epibromohydrin. Efficient synthesis of 6-hydroxymethyl-5,6-dihydro-4H-1,2- oxazines and oxazolo[3,4-b]pyridazin-7-ones". . p. 2293 - 2301. Retrieved 2007/10/03.
• 2、 South, Michael S.,Jakuboski, Terri L.,Westmeyer, Mark D.,Dukesherer, Daniel R.. "Novel cyclization reactions of dichloroazodienes". . p. 1351 - 1354. Retrieved 2007/10/03.