Butanoic acid, 4,4'-dithiobis[2-[(trifluoroacetyl)amino]-, (2S,2'S)-

Base Information

• Chemical Name: Butanoic acid, 4,4'-dithiobis[2-[(trifluoroacetyl)amino]-, (2S,2'S)-
• CAS No.: 255387-50-9
• Molecular Formula: C12H14F6N2O6S2
• Molecular Weight: 460.37000
• Mol file: 255387-50-9.mol

Synonyms:(S)-4-[(S)-3-Carboxy-3-(2,2,2-trifluoro-acetylamino)-propyldisulfanyl]-2-(2,2,2-trifluoro-acetylamino)-butyric acid;

Chemical Property of Butanoic acid, 4,4'-dithiobis[2-[(trifluoroacetyl)amino]-, (2S,2'S)-

Chemical Property:

• PSA: 183.40000
• LogP: 2.19320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 4,4'-dithiobis[2-[(trifluoroacetyl)amino]-, (2S,2'S)-

There total 1 articles about Butanoic acid, 4,4'-dithiobis[2-[(trifluoroacetyl)amino]-, (2S,2'S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

L-homocystine (626-72-2,870-93-9,6027-15-2,7093-69-8,462-10-2) + ethyl trifluoroacetate, (383-63-1) → bis-N-trifluoroacetyl homocysteine (255387-50-9)

Guidance literature:

With potassium methanolate; In methanol; at 20 ℃;

DOI:10.1016/j.tet.2003.02.002

Reference yield: 90.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + bis-N-trifluoroacetyl homocysteine (255387-50-9) → Fmoc-L-homocystine (181370-86-5)

Guidance literature:

bis-N-trifluoroacetyl homocysteine; With sodium carbonate; In water; at 25 ℃; for 12h;

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide; In 1,4-dioxane; water; at 25 ℃; for 4h;

With citric acid; In 1,4-dioxane; water; pH=4;

DOI:10.1016/S0040-4020(02)01086-4

upstream raw materials:

L-homocystine

ethyl trifluoroacetate,

Downstream raw materials:

Fmoc-L-homocystine

Refernces