Bay 41-2272

Base Information Edit

Chemical Name:Bay 41-2272
CAS No.:256376-24-6
Molecular Formula:C20H17FN6
Molecular Weight:360.394
Hs Code.:
European Community (EC) Number:636-738-0
UNII:34A162J6WB
DSSTox Substance ID:DTXSID90180320
Nikkaji Number:J1.500.688I
Wikidata:Q27074887
ChEMBL ID:CHEMBL353759
Mol file:256376-24-6.mol

Synonyms:3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine;BAY 41-2272;BAY412272

Suppliers and Price of Bay 41-2272

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
BAY41-2272
10mg
$ 110.00

TRC
BAY41-2272
25mg
$ 225.00

Sigma-Aldrich
BAY 41-2272 - CAS 256376-24-6 - Calbiochem
5mg
$ 203.00

DC Chemicals
BAY41-2272 >98%
1 g
$ 1700.00

CSNpharm
BAY41-2272
100mg
$ 836.00

CSNpharm
BAY41-2272
10mg
$ 143.00

CSNpharm
BAY41-2272
5mg
$ 82.00

ChemScene
BAY41-2272 99.97%
25mg
$ 348.00

ChemScene
BAY41-2272 99.97%
10mg
$ 168.00

ChemScene
BAY41-2272 99.97%
5mg
$ 96.00

Total 12 raw suppliers

Chemical Property of Bay 41-2272 Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:210.5-211.4?°C
Boiling Point:496.08oC at 760 mmHg
PKA:2.71±0.10(Predicted)
Flash Point:253.82oC
PSA：83.24000
Density:1.494g/cm3
LogP:3.46540
Storage Temp.:2-8°C
Solubility.:DMSO: 26 mg/mL at 60 °C
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:360.14987273
Heavy Atom Count:27
Complexity:517

Purity/Quality:

99%+, ^*data from raw suppliers

BAY41-2272 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F
Description Soluble guanylate cyclase (sGC), a receptor for nitric oxide (NO), is a heterodimer consisting of alpha and beta subunits, with the beta subunit featuring a heme-nitric oxide (H-NOX) binding domain. The binding of NO to H-NOX induces sGC to generate the second messenger cGMP. BAY 41-2272 is a pyrazolopyridine compound that acts as an activator of sGC, stimulating activity to a level that would be expected to cause biologically important increases in cGMP at concentrations as low as 10-100 nM. Through this effect, it inhibits platelet aggregation (IC50 = 36 nM), induces relaxation of phenylephrine-preconstricted rabbit aorta rings (IC50 = 304 nM), and reduces proliferation in smooth muscle. BAY 41-2272 is effective in vivo, as it decreases mean arterial blood pressure in hypertensive rats. Unlike another sGC activator, YC-1 , BAY 41-2772 does not inhibit phosphodiesterases.
Uses BAY 41-2272 is a soluble guanylate cyclase agonist that activates human mononuclear phagocytes. Inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways.

Technology Process of Bay 41-2272

There total 11 articles about Bay 41-2272 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%