1-(3-BROMOPROPOXY)-2-BROMOBENZENE

Base Information

• Chemical Name: 1-(3-BROMOPROPOXY)-2-BROMOBENZENE
• CAS No.: 37136-84-8
• Molecular Formula: C9H10 Br2 O
• Molecular Weight: 293.986
• Hs Code.: 2909309090
• Mol file: 37136-84-8.mol

Synonyms:Ether,o-bromophenyl 3-bromopropyl (5CI); 2-Bromophenyl 3-bromopropyl ether; NSC338426

Chemical Property of 1-(3-BROMOPROPOXY)-2-BROMOBENZENE

Chemical Property:

• Vapor Pressure: 0.000677mmHg at 25°C
• Boiling Point: 318.4°Cat760mmHg
• Flash Point: 128.6°C
• PSA: 9.23000
• Density: 1.672g/cm³
• LogP: 3.61290
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Bromo-2-(3-bromopropoxy)benzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-BROMOPROPOXY)-2-BROMOBENZENE

There total 1 articles about 1-(3-BROMOPROPOXY)-2-BROMOBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-hydroxybromobenzene (95-56-7) + 1,3-dibromo-propane (109-64-8) → 2-bromophenyl 3-bromopropyl ether (37136-84-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

DOI:10.1021/ja5026276

Reference yield: 76.0%

1H-indol-2-ylcarboxaldehyde (19005-93-7) + 2-bromophenyl 3-bromopropyl ether (37136-84-8) → 1-(3-(2-bromophenoxy)propyl)-1H-indole-2-carbaldehyde

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 64.0%

N-(2-methylbenzoyl)-8-aminoquinoline (1182669-71-1) + 2-bromophenyl 3-bromopropyl ether (37136-84-8) → 2-(3-(2-bromophenoxy)propyl)-6-methyl-N-(quinolin-8-yl)benzamide

Guidance literature:

With chromium chloride; phenylmagnesium bromide; 1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride; In 2-methyltetrahydrofuran; at 40 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c8cc05026k

upstream raw materials:

2-hydroxybromobenzene

1,3-dibromo-propane

Downstream raw materials:

C₁₃H₁₉BrN₂O

Refernces

• 1、 Zhou, Xiaotian,Lin, Kuaile,Ma, Xiang,Chui, Wai-Keung,Zhou, Weicheng. "Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors". . p. 1279 - 1288. Retrieved 2016/11/29.
• 2、 Che, Xiaoying,Sheng, Chunquan,Wang, Wenya,Cao, Yongbing,Xu, Yulan,Ji, Haitao,Dong, Guoqiang,Miao, Zhenyuan,Yao, Jianzhong,Zhang, Wannian. "New azoles with potent antifungal activity: Design, synthesis and molecular docking". scheme or table. p. 4218 - 4226. Retrieved 2009/12/09.