4-(morpholin-4-yl)quinazoline

Base Information

• Chemical Name: 4-(morpholin-4-yl)quinazoline
• CAS No.: 7471-81-0
• Molecular Formula: C12H13 N3 O
• Molecular Weight: 215.2511
• Mol file: 7471-81-0.mol

Synonyms:Quinazoline,4-morpholino- (8CI); 4-(Morpholino)quinazoline; NSC 401286

Chemical Property of 4-(morpholin-4-yl)quinazoline

Chemical Property:

• Vapor Pressure: 1.36E-06mmHg at 25°C
• Boiling Point: 399.5°Cat760mmHg
• Flash Point: 195.4°C
• Density: 1.242g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(morpholin-4-yl)quinazoline

There total 7 articles about 4-(morpholin-4-yl)quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + 4-chloroquinazoline (5190-68-1) → 4-(quinazolin-4-yl)morpholine (7471-81-0)

Guidance literature:

In 1,4-dioxane; for 3h; Inert atmosphere; Reflux;

DOI:10.1002/asia.202100534

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + quinazoline (253-82-7) → 4-(quinazolin-4-yl)morpholine (7471-81-0)

Guidance literature:

With AgPy₂MNo₄; at 8 - 10 ℃; for 0.5h;

DOI:10.1002/ejoc.200600573

Reference yield: 78.0%

morpholine (110-91-8,99108-56-2) → 4-(quinazolin-4-yl)morpholine (7471-81-0)

Guidance literature:

In water; at 100 ℃; for 1h; Sealed tube; Microwave irradiation;

DOI:10.1021/acs.joc.8b01824

upstream raw materials:

morpholine

quinazoline-4(3H)-thione

4-chloroquinazoline

quinazoline

Refernces

• 1、 Tankam, Theeranon,Srisa, Jakkrit,Sukwattanasinitt, Mongkol,Wacharasindhu, Sumrit. "Microwave-Enhanced On-Water Amination of 2-Mercaptobenzoxazoles to Prepare 2-Aminobenzoxazoles". . p. 11936 - 11943. Retrieved 2018/10/02.
• 2、 Walsh, Katie,Sneddon, Helen F.,Moody, Christopher J.. "Amination of heteroaryl chlorides: Palladium catalysis or SNAr in green solvents?". . p. 1455 - 1460. Retrieved 2013/09/12.