N-Acetyl L-Thyroxine

Base Information

• Chemical Name: N-Acetyl L-Thyroxine
• CAS No.: 26041-51-0
• Molecular Formula: C17H13I4NO5
• Molecular Weight: 818.912
• Mol file: 26041-51-0.mol

Synonyms:N-Acetyl-O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine;

Chemical Property of N-Acetyl L-Thyroxine

Chemical Property:

• Melting Point: 210-215 °C (decomp)
• Boiling Point: 671.8±55.0 °C(Predicted)
• PKA: 2.95±0.10(Predicted)
• PSA: 99.35000
• Density: 2.481±0.06 g/cm3(Predicted)
• LogP: 5.57500
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-AcetylL-Thyroxine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-Acetyl L-Thyroxine is the Thyroxine (T425600) analogue, a thyroid hormone for use in diagnosing and treating diabetes.

Technology Process of N-Acetyl L-Thyroxine

There total 9 articles about N-Acetyl L-Thyroxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl (S)-2-acetamido-3-(4-(4-acetoxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoate → (S)-2-acetamido-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid (26041-51-0)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

L-thyroxine (51-48-9,24486-40-6) + acetic anhydride (108-24-7) → (S)-2-acetamido-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid (26041-51-0)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

Reference yield:

L-thyroxine (51-48-9,24486-40-6) + acetic acid (64-19-7,77671-22-8) → (S)-2-acetamido-3-(4-(4-hydroxy-3,5-diaiodophenoxy)-3,5-diaiodophenyl)propanoic acid (26041-51-0)

Guidance literature:

acetic acid; With 1-hydroxy-pyrrolidine-2,5-dione; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 - 25 ℃; Inert atmosphere;

L-thyroxine; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

upstream raw materials:

N-acetyl-3,5-diiodo-L-tyrosine

3.5-diiodo-N.O-diacetyl-L-tyrosine

L-thyroxine

acetic anhydride

Downstream raw materials:

C₂₁H₁₆I₄N₂O₇

Refernces

• 1、 -. "Novel derivatives of thyroid hormone and use of thereof". Paragraph 0068-0069; 0073. . Retrieved 2020/07/28.
• 2、 -. "NANOPARTICLE AND POLYMER FORMULATIONS FOR THYROID HORMONE ANALOGS, ANTAGONISTS, AND FORMULATIONS THEREOF". Page/Page column 162; 163. . Retrieved 2008/12/05.