4-methoxy-2-phenylquinazoline

Base Information

• Chemical Name: 4-methoxy-2-phenylquinazoline
• CAS No.: 26060-03-7
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol file: 26060-03-7.mol

Synonyms:4-Methoxy-2-phenyl-quinazoline;4-Methoxy-2-phenyl-chinazolin;

Chemical Property of 4-methoxy-2-phenylquinazoline

Chemical Property:

• Melting Point: 49 - 50 °C
• PSA: 35.01000
• LogP: 3.30540

Purity/Quality:

4-METHOXY-2-PHENYLQUINAZOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methoxy-2-phenylquinazoline

There total 11 articles about 4-methoxy-2-phenylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-phenyl-5H-1,4,2-dioxazol-5-one (19226-36-9) + methyl benzimidate (7471-86-5) → 4-Methoxy-2-phenylquinazoline (26060-03-7)

Guidance literature:

With silver tetrafluoroborate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; In 1,2-dichloro-ethane; at 50 ℃; for 5h; Glovebox;

DOI:10.1021/acs.orglett.6b00691

Reference yield: 95.0%

4-chloro-2-phenylquinazoline (6484-25-9) + sodium methylate (124-41-4) → 4-Methoxy-2-phenylquinazoline (26060-03-7)

Guidance literature:

In methanol; for 1h; Heating;

DOI:10.1007/BF00958004

Reference yield: 92.0%

4-chloro-2-phenylquinazoline (6484-25-9) → 4-Methoxy-2-phenylquinazoline (26060-03-7)

Guidance literature:

With sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

upstream raw materials:

N-(2-cyanophenyl)benzamide

sodium methylate

4-chloro-2-phenylquinazoline

5-Methoxy-2-phenyl-3H-benzo[e][1,4]diazepine

Downstream raw materials:

4-amino-2-phenyl-quinazoline

2-phenyl-4(3H)-quinazolinone

Refernces

• 1、 Wang, Jie,Zha, Shanke,Chen, Kehao,Zhang, Feifei,Song, Chao,Zhu, Jin. "Quinazoline synthesis via Rh(III)-catalyzed intermolecular C-H functionalization of benzimidates with dioxazolones". supporting information. p. 2062 - 2065. Retrieved 2016/06/06.
• 2、 Wang, Hui,Lorion, Mélanie M.,Ackermann, Lutz. "Overcoming the Limitations of C?H Activation with Strongly Coordinating N-Heterocycles by Cobalt Catalysis". supporting information. p. 10386 - 10390. Retrieved 2016/08/24.