2-Methoxy-6-methylnaphthalene

Base Information

• Chemical Name: 2-Methoxy-6-methylnaphthalene
• CAS No.: 26386-94-7
• Molecular Formula: C12H12O
• Molecular Weight: 172.227
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID80452068
• Nikkaji Number: J470.882B
• Wikidata: Q82272436
• Mol file: 26386-94-7.mol

Synonyms:2-METHOXY-6-METHYLNAPHTHALENE;26386-94-7;6-methoxy-2-methylnaphthalene;Naphthalene, 2-methoxy-6-methyl-;SCHEMBL7750;2-methyl-6-methoxynaphthalene;DTXSID80452068;JWXYEXKKOMBZBH-UHFFFAOYSA-N;AKOS006346571;FT-0757749;N14597

Chemical Property of 2-Methoxy-6-methylnaphthalene

Chemical Property:

• PSA: 9.23000
• LogP: 3.15680
• Storage Temp.: 2-8°C
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 172.088815002
• Heavy Atom Count: 13
• Complexity: 167

Purity/Quality:

95% ^*data from raw suppliers

2-Methoxy-6-methylnaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)C=C(C=C2)OC

Technology Process of 2-Methoxy-6-methylnaphthalene

There total 22 articles about 2-Methoxy-6-methylnaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-Bromo-6-methoxynaphthalene (5111-65-9) + lithium methyltriolborate → 2-methyl-6-methoxynaphthalene (26386-94-7)

Guidance literature:

With palladium diacetate; ruphos; In methanol; water; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.3390/molecules18010430

Reference yield: 86.0%

6-methoxynaphthalene-2-carbaldehyde (3453-33-6) → 2-methyl-6-methoxynaphthalene (26386-94-7)

Guidance literature:

With potassium hydroxide; hydrazine; In diethylene glycol; at 20 - 165 ℃; for 22h;

DOI:10.1016/S0040-4020(02)00495-7

Reference yield: 81.0%

5-methoxy-2-(2-methylallyl)benzaldehyde (1228753-03-4) → 2-methyl-6-methoxynaphthalene (26386-94-7)

Guidance literature:

With tin (IV) chloride pentahydrate; In dichloromethane; at 20 ℃; Solvent;

DOI:10.1016/j.tet.2016.02.033

upstream raw materials:

methanol

2-methyl-6-hydroxynaphthalene

dimethyl sulfate

2-Bromo-6-methoxynaphthalene

Downstream raw materials:

2-methyl-6-hydroxynaphthalene

2-(chloromethyl)-6-methoxynaphthalene

2-(Bromomethyl)-6-methoxynaphthalene

[2-(6-methoxy)-naphthyl](4-methylphenyl)methanol

Refernces

• 1、 Cook, Adam,Prakash, Sekar,Zheng, Yan-Long,Newman, Stephen G.. "Exhaustive Reduction of Esters Enabled by Nickel Catalysis". supporting information. p. 8109 - 8115. Retrieved 2020/05/20.
• 2、 Okita, Toshimasa,Muto, Kei,Yamaguchi, Junichiro. "Decarbonylative Methylation of Aromatic Esters by a Nickel Catalyst". supporting information. p. 3132 - 3135. Retrieved 2018/05/28.