4-(1-Benzofuran-2-yl)phenol

Base Information

• Chemical Name: 4-(1-Benzofuran-2-yl)phenol
• CAS No.: 26870-36-0
• Molecular Formula: C14H10O2
• Molecular Weight: 210.232
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID40435872
• Nikkaji Number: J1.223.742A
• Wikidata: Q82250993
• ChEMBL ID: CHEMBL3794402
• Mol file: 26870-36-0.mol

Synonyms:4-(BENZOFURAN-2-YL)PHENOL;4-(1-Benzofuran-2-yl)phenol;26870-36-0;4-(2-Benzofuranyl)phenol;4-(2-Benzofuranyl)-phenol;CHEMBL3794402;2-p-hydroxyphenylbenzofuran;2-(4-hydroxyphenyl)benzofuran;Phenol, 4-(2-benzofuranyl)-;SCHEMBL5032926;DTXSID40435872;YTEKHDAKURIPLM-UHFFFAOYSA-N;BDBM50162937;MFCD17677569;CS-0336105;Z1513804762

Chemical Property of 4-(1-Benzofuran-2-yl)phenol

Chemical Property:

• PSA: 33.37000
• LogP: 3.80540
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 210.068079557
• Heavy Atom Count: 16
• Complexity: 233

Purity/Quality:

99% ^*data from raw suppliers

4-(1-BENZOFURAN-2-YL)PHENOL 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(O2)C3=CC=C(C=C3)O

Technology Process of 4-(1-Benzofuran-2-yl)phenol

There total 21 articles about 4-(1-Benzofuran-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(p-methoxyphenyl)-benzo[b]furan (19234-04-9) → 2-(4-hydroxyphenyl)benzo[b]furan (26870-36-0)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1016/S0040-4039(99)02030-4

Reference yield: 98.0%

2-(2-methoxyphenyl)-1-(4-methoxyphenyl)ethan-1-one (65200-70-6) → 2-(4-hydroxyphenyl)benzo[b]furan (26870-36-0)

Guidance literature:

With hydrogen bromide; In acetic acid; for 8h; Reflux;

DOI:10.1016/j.tet.2013.12.050

Reference yield: 84.0%

(E)-1-(4-hydroxyphenyl)ethanone O-phenyloxime (701262-43-3) → 2-(4-hydroxyphenyl)benzo[b]furan (26870-36-0)

Guidance literature:

(E)-1-(4-hydroxyphenyl)ethanone O-phenyloxime; With dmap; trifluoroacetyl triflate; In dichloromethane; at 20 ℃; for 2h;

With silica gel;

DOI:10.1021/ol049564o

upstream raw materials:

2-(p-methoxyphenyl)-benzo[b]furan

2-(2-methoxyphenyl)-1-(4-methoxyphenyl)ethan-1-one

(E)-1-(4-hydroxyphenyl)ethanone O-phenyloxime

O-phenylhydroxylamine

Downstream raw materials:

2-(4-(3-bromopropoxy)phenyl)benzofuran

C₁₇H₁₇NO₂

C₁₈H₁₉NO₂

2-(4-(2-bromoethoxy)phenyl)benzofuran

Refernces

• 1、 Fujita, Takeshi,Morioka, Ryutaro,Fukuda, Takuya,Suzuki, Naoto,Ichikawa, Junji. "Acid-mediated intermolecular C-F/C-H cross-coupling of 2-fluorobenzofurans with arenes: Synthesis of 2-arylbenzofurans". supporting information. p. 8500 - 8503. Retrieved 2021/08/31.
• 2、 -. "ALIGNMENT COMPOUNDS". Paragraph 0145. . Retrieved 2017/01/31.