N-cyclohexyl-3-nitrobenzamide

Base Information

• Chemical Name: N-cyclohexyl-3-nitrobenzamide
• CAS No.: 2702-32-1
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.27800
• Hs Code.: 2924299090
• Mol file: 2702-32-1.mol

Synonyms:Benzamide,N-cyclohexyl-m-nitro;m-Nitrobenzoyl-cyclohexylamid;Benzamide,N-cyclohexyl-3-nitro;

Chemical Property of N-cyclohexyl-3-nitrobenzamide

Chemical Property:

• PSA: 78.41000
• LogP: 3.75530

Purity/Quality:

95% ^*data from raw suppliers

N-cyclohexyl-3-nitrobenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-cyclohexyl-3-nitrobenzamide

There total 8 articles about N-cyclohexyl-3-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Cyclohexyl isocyanide (931-53-3) + 3-nitrobenzoic acid (121-92-6) → N-cyclohexyl-3-nitrobenzamide (2702-32-1)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.06.136

Reference yield: 70.0%

m-nitrobromobenzene (585-79-5) + dicyclohexyl-carbodiimide (538-75-0) → N-cyclohexyl-3-nitrobenzamide (2702-32-1)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]nickel(II) chloride; magnesium chloride; zinc; In N,N-dimethyl-formamide; at 70 ℃; for 20h;

DOI:10.1002/ejoc.201501349

Reference yield: 60.0%

1-methyl-3-nitrobenzene (99-08-1) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexyl-3-nitrobenzamide (2702-32-1)

Guidance literature:

With tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; In water; at 20 ℃; for 16h; Schlenk technique; Green chemistry;

DOI:10.1039/d1nj03982b

upstream raw materials:

cyclohexylamine

m-nitrobenzoic acid chloride

m-nitrobenzoyl bromide

3-nitro-benzaldehyde

Downstream raw materials:

C₁₅H₂₃N₃O₃S

3-amino-benzoic acid cyclohexylamide

Refernces

• 1、 Panahi, Farhad,Jamedi, Fereshteh,Iranpoor, Nasser. "Nickel-Catalyzed Reductive Addition of Aryl/Benzyl Halides and Pseudohalides to Carbodiimides for the Synthesis of Amides". . p. 780 - 788. Retrieved 2017/01/18.
• 2、 Shaabani, Ahmad,Soleimani, Ebrahim,Rezayan, Ali Hossein. "A novel approach for the synthesis of aryl amides". . p. 6137 - 6141. Retrieved 2008/03/12.