2-Phenyl-5H-imidazo[2,1-a]isoindole

Base Information

• Chemical Name: 2-Phenyl-5H-imidazo[2,1-a]isoindole
• CAS No.: 61001-00-1
• Molecular Formula: C16H12 N2
• Molecular Weight: 232.2799
• Mol file: 61001-00-1.mol

Synonyms:L 11730

Chemical Property of 2-Phenyl-5H-imidazo[2,1-a]isoindole

Chemical Property:

• Vapor Pressure: 6.71E-09mmHg at 25°C
• Boiling Point: 467.1°C at 760 mmHg
• Flash Point: 236.3°C
• PSA: 17.82000
• Density: 1.21g/cm³
• LogP: 3.57880

Purity/Quality:

2-PHENYL-5H-IMIDAZO[2,1-A]ISOINDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Phenyl-5H-imidazo[2,1-a]isoindole

There total 9 articles about 2-Phenyl-5H-imidazo[2,1-a]isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-phenyl-5H-imidazo<2,1-a>isoindole hydrochloride (61001-46-5) → 2-phenyl-5H-imidazo<2,1-a>isoindole (61001-00-1)

Guidance literature:

With sodium carbonate; In water;

Reference yield: 58.0%

C16H13BrN2 → 2-phenyl-5H-imidazo<2,1-a>isoindole (61001-00-1)

Guidance literature:

With potassium phosphate; copper(l) iodide; 1,10-Phenanthroline; In o-xylene; N,N-dimethyl-formamide; at 20 - 145 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/cjoc.201300399

Reference yield: 50.0%

1-benzyl-4-phenyl-1H-imidazole (53704-77-1) → 2-phenyl-5H-imidazo<2,1-a>isoindole (61001-00-1)

Guidance literature:

With palladium diacetate; silver trifluoroacetate; Trimethylacetic acid; at 150 ℃; for 48h; Inert atmosphere;

DOI:10.1002/ejoc.201901618

upstream raw materials:

2-phenyl-5H-imidazo<2,1-a>isoindole hydrochloride

1-aminoisoindole hydrochloride

α-bromoacetophenone

1-benzyl-4-phenyl-1H-imidazole

Refernces

• 1、 Huang, Yuan,Chen, Wei,Zhao, Dan,Chen, Chen,Yin, Huiqing,Zheng, Likang,Jin, Ming,Han, Shiqing. "Copper(I)-catalyzed intramolecular direct C-arylation of azoles with aryl bromides". supporting information. p. 1007 - 1010. Retrieved 2013/09/02.
• 2、 -. "Antireproductive imidazo[2,1-a]isoquinoline compounds". . . Retrieved 2008/06/13.