4-Ethylbenzotrifluoride

Base Information

• Chemical Name: 4-Ethylbenzotrifluoride
• CAS No.: 27190-69-8
• Molecular Formula: C9H9F3
• Molecular Weight: 174.166
• Hs Code.: 2903999090
• Mol file: 27190-69-8.mol

Synonyms:1-ethyl-4-(isopropylidenehydrazino)-1H-pyrazolo-(3,4-b)-pyridine-5-carboxylic acid ethyl ester hydrochloride;1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid,1-ethyl-4-[(1-methylethylidene)hydrazino]-,ethyl ester,monohydrochloride;Etazolate hydrochloride;1-ethyl-4-trifluoromethylbenzene;1-ethyl-4-[(1-methylethylidene)hydrazino]1h-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride;1-Ethyl-4-trifluormethylbenzol;(4-(trifluoromethyl)phenyl)ethane;

Chemical Property of 4-Ethylbenzotrifluoride

Chemical Property:

• PSA: 0.00000
• LogP: 3.26780

Purity/Quality:

98%min ^*data from raw suppliers

4-Ethylbenzotrifluoride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 4-Ethylbenzotrifluoride

There total 26 articles about 4-Ethylbenzotrifluoride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-trifluoromethyl-4-vinyl-benzene (402-50-6) → 1-ethyl-4-(trifluoromethyl)benzene (27190-69-8)

Guidance literature:

With water; palladium diacetate; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In dichloromethane; at 25 ℃; for 12h; Schlenk technique; Inert atmosphere;

Reference yield: 80.0%

1-(4-trifluoromethylphenyl)ethanone (709-63-7) → 1-ethyl-4-(trifluoromethyl)benzene (27190-69-8)

Guidance literature:

With sodium hypophosphite monohydrate; 5%-palladium/activated carbon; hypophosphorous acid; In water; at 100 ℃;

DOI:10.1016/j.tet.2014.02.014

Reference yield: 60.0%

4-Iodobenzotrifluoride (455-13-0) → 1-ethyl-4-(trifluoromethyl)benzene (27190-69-8)

Guidance literature:

With triphenylphosphine; {PdWcp[μ-(CO)2][μ3-(CO)](PPh3)}2; In benzene; at 78 ℃; for 2h;

DOI:10.1055/s-2005-921749

upstream raw materials:

1-(4-trifluoromethylphenyl)ethanone

piperidine

1-trifluoromethyl-4-vinyl-benzene

(S)-1-phenyl-N-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)ethan-1-amine

Downstream raw materials:

1-(1-chloroethyl)-4-(trifluoromethyl)benzene

2-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridine

1-(4-trifluoromethylphenyl)ethanone

[2-ethyl-5-(trifluoromethyl)phenyl]boronic acid

Refernces

• 1、 Lücke, Marcel-Philip,Yao, Shenglai,Driess, Matthias. "Boosting homogeneous chemoselective hydrogenation of olefins mediated by a bis(silylenyl)terphenyl-nickel(0) pre-catalyst". . p. 2909 - 2915. Retrieved 2021/03/14.
• 2、 Beller, Matthias,Feng, Lu,Gao, Jie,Jackstell, Ralf,Jagadeesh, Rajenahally V.,Liu, Yuefeng,Ma, Rui. "Ambient Hydrogenation and Deuteration of Alkenes Using a Nanostructured Ni-Core–Shell Catalyst". supporting information. p. 18591 - 18598. Retrieved 2021/06/28.