Cyclopentanol, 2-[(4-methylphenyl)amino]-, (1R,2R)-rel- (9CI)

Base Information

• Chemical Name: Cyclopentanol, 2-[(4-methylphenyl)amino]-, (1R,2R)-rel- (9CI)
• CAS No.: 273218-43-2
• Molecular Formula: C12H17NO
• Molecular Weight: 191.26900
• Mol file: 273218-43-2.mol

Synonyms:

Chemical Property of Cyclopentanol, 2-[(4-methylphenyl)amino]-, (1R,2R)-rel- (9CI)

Chemical Property:

• PSA: 32.26000
• LogP: 2.39330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopentanol, 2-[(4-methylphenyl)amino]-, (1R,2R)-rel- (9CI)

There total 5 articles about Cyclopentanol, 2-[(4-methylphenyl)amino]-, (1R,2R)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Cyclopentene oxide (285-67-6) + p-toluidine (106-49-0,12221-03-3) → 2-(p-tolylamino)cyclopentan-1-ol (273218-43-2)

Guidance literature:

With zinc(II) chloride; In tetrahydrofuran; at 80 ℃; for 8h; Schlenk technique;

DOI:10.1080/00304948.2021.1994289

Reference yield: 96.0%

Cyclopentene oxide (285-67-6) + p-toluidine (106-49-0,12221-03-3) → (1S,2S)-2-p-Tolylamino-cyclopentanol (273218-43-2)

Guidance literature:

With BiCl₆^(3-)*2C₄H₁₀N₂*ClH*3H⁽¹⁺⁾*H₂O; at 20 ℃; for 0.133333h; diastereospecific reaction; Neat (no solvent);

DOI:10.1016/j.tetlet.2012.05.079

Reference yield: 90.0%

Cyclopentene oxide (285-67-6) + p-toluidine (106-49-0,12221-03-3) → C12H17NO (1498991-83-5,273218-43-2)

Guidance literature:

With ferrocenium(III) tetrafluoroborate; In neat (no solvent); at 0 - 25 ℃; for 5h; regioselective reaction;

DOI:10.1055/s-0033-1340498

upstream raw materials:

Cyclopentene oxide

p-toluidine

(1S,5R)-6-Oxa-bicyclo[3.1.0]hexane

Refernces

• 1、 Sheoran, Ankush,Kaur, Jaspreet,Kaur, Paramdeep,Kumar, Vinod,Tikoo,Agarwal, Jyoti,Bansal,Singhal, Sonal. "Graphene based magnetic nanohybrids as promising catalysts for the green synthesis of β-amino alcohol derivatives". . . Retrieved 2019/12/23.
• 2、 Yadav, Geeta Devi,Chauhan, Manmohan Singh,Singh, Surendra. "Fe(Cp)2BF4: An efficient lewis acid catalyst for the aminolysis of epoxides". . p. 629 - 634. Retrieved 2014/03/21.