Thiazolo[4,5-D]pyridazine

Base Information

• Chemical Name: Thiazolo[4,5-D]pyridazine
• CAS No.: 273-76-7
• Molecular Formula: C5H3N3S
• Molecular Weight: 137.16200
• DSSTox Substance ID: DTXSID80595984
• Wikidata: Q82491106
• Mol file: 273-76-7.mol

Synonyms:THIAZOLO[4,5-D]PYRIDAZINE;273-76-7;[1,3]Thiazolo[4,5-d]pyridazine;SCHEMBL209182;DTXSID80595984;AKOS006373189

Chemical Property of Thiazolo[4,5-D]pyridazine

Chemical Property:

• PSA: 66.91000
• LogP: 1.08630
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 137.00476828
• Heavy Atom Count: 9
• Complexity: 108

Purity/Quality:

THIAZOLO-[4,5-D]PYRIDAZINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C2C(=CN=N1)SC=N2

Technology Process of Thiazolo[4,5-D]pyridazine

There total 3 articles about Thiazolo[4,5-D]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,5-Diformyl-thiazol (13669-78-8) → Thiazolo<4,5-d>pyridazin (273-76-7)

Guidance literature:

With hydrazine; In ethanol; Ambient temperature;

Reference yield:

thiazole-4,5-dicarbonitrile (98027-78-2) → Thiazolo<4,5-d>pyridazin (273-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iBu₂AlH

2: N₂H₄ / ethanol / Ambient temperature

With diisobutylaluminium hydride; hydrazine; In ethanol;

Reference yield:

→ Thiazolo<4,5-d>pyridazin (273-76-7)

Guidance literature:

2, Hydrazinhydrat;

upstream raw materials:

4,5-Diformyl-thiazol

thiazole-4,5-dicarbonitrile