4'-Aminobiphenyl-4-Sulfonamide

Base Information

• Chemical Name: 4'-Aminobiphenyl-4-Sulfonamide
• CAS No.: 100142-87-8
• Molecular Formula: C12H12 N2 O2 S
• Molecular Weight: 248.305
• Hs Code.: 2935009090
• European Community (EC) Number: 808-382-8
• ChEMBL ID: CHEMBL3632831
• DSSTox Substance ID: DTXSID30406970
• Pharos Ligand ID: QYA66CG2GN1L
• Wikidata: Q27458321
• Mol file: 100142-87-8.mol

Synonyms:100142-87-8;4-(4-aminophenyl)benzenesulfonamide;4'-amino-1,1'-biphenyl-4-sulfonamide;4'-Aminobiphenyl-4-Sulfonamide;CHEMBL3632831;4-(4-aminophenyl)benzene-1-sulfonamide;4'-Amino-[1,1'-biphenyl]-4-sulfonamide;4/'/'-AMINO-1,1/'/'-BIPHENYL-4-SULFONAMIDE;SCHEMBL2496721;EX-A7842W;DTXSID30406970;BDBM50133395;AKOS000122827;CS-0350883;EN300-12487;Q27458321;BC5

Chemical Property of 4'-Aminobiphenyl-4-Sulfonamide

Chemical Property:

• Boiling Point: 471.3°Cat760mmHg
• Flash Point: 238.9°C
• PSA: 94.56000
• Density: 1.335g/cm³
• LogP: 3.94550
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 248.06194880
• Heavy Atom Count: 17
• Complexity: 334

Purity/Quality:

97% ^*data from raw suppliers

4'-AMINO-1,1'-BIPHENYL-4-SULFONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)S(=O)(=O)N)N

Technology Process of 4'-Aminobiphenyl-4-Sulfonamide

There total 8 articles about 4'-Aminobiphenyl-4-Sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

4-bromo-aniline (106-40-1) + benzenesulfonamide-4-boronic acid pinacol ester (214360-51-7) → 4-sulfamoyl-1,1'-biphenyl-4'-amine (100142-87-8)

Guidance literature:

With palladium diacetate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; water; at 25 - 110 ℃; under 12929 Torr; Microwave irradiation;

DOI:10.1021/acs.jmedchem.5b01144

Reference yield:

4'-acetylamino-biphenyl-4-sulfonic acid amide (873411-51-9) → 4-sulfamoyl-1,1'-biphenyl-4'-amine (100142-87-8)

Guidance literature:

With hydrogenchloride;

DOI:10.1021/ja01868a069 DOI:10.1021/ja01233a041 DOI:10.1021/ja01847a506

Reference yield:

→ 4-sulfamoyl-1,1'-biphenyl-4'-amine (100142-87-8)

Guidance literature:

With hydrogenchloride; tin; ethanol;

DOI:10.1021/ja01848a061 DOI:10.1021/ja01849a502

upstream raw materials:

4'-acetylamino-biphenyl-4-sulfonic acid amide

4-phenylalanine

chlorosulfonic acid

4-phenylacetanilide

Refernces