1-benzyl-3-broMobenzene

Base Information

• Chemical Name: 1-benzyl-3-broMobenzene
• CAS No.: 27798-39-6
• Molecular Formula: C13H11Br
• Molecular Weight: 247.134
• Hs Code.: 2903999090
• Mol file: 27798-39-6.mol

Synonyms:1-bromo-3-benzylbenzene;1-Benzyl-3-bromo-benzene;3-benzylbromobenzene;3-Bromodiphenylmethane;

Chemical Property of 1-benzyl-3-broMobenzene

Chemical Property:

• PSA: 0.00000
• LogP: 4.03990
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

98.5% ^*data from raw suppliers

1-Benzyl-3-bromobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Benzyl-3-bromobenzene is used in the synthesis of inhibitors of HIV-1 integrase. It is also used to prepare C-arylglucoside inhibitors of renal sodium-dependent glucose transporter SGLT2.

Technology Process of 1-benzyl-3-broMobenzene

There total 18 articles about 1-benzyl-3-broMobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(3-Bromophenyl)methanol (15852-73-0) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 1-benzyl-3-bromobenzene (27798-39-6)

Guidance literature:

With boron trifluoride diethyl etherate; at 80 ℃; for 2h;

DOI:10.1016/j.tetlet.2014.06.047

Reference yield: 93.5%

3-bromobenzophenone (1016-77-9) → 1-benzyl-3-bromobenzene (27798-39-6)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethylene glycol; at 155 - 198 ℃; for 9.5h;

Reference yield: 91.0%

(3-bromophenyl)boronic acid (89598-96-9) + benzyl chloride (100-44-7) → 1-benzyl-3-bromobenzene (27798-39-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 4h; Inert atmosphere; Large scale reaction;

DOI:10.1002/ejoc.200800544

upstream raw materials:

3-bromobenzophenone

bromobenzene

benzaldehyde

1,3-dibromobenzene

Downstream raw materials:

1-(3-benzylphenyl)ethan-1-one

(3-benzylphenyl){8-[(2-methoxyethoxy)-methoxy]-4-methylquinolin-7-yl }methanone

(3-benzylphenyl)boronic acid

3''-benzyl-2'-isobutyl-3-isopropyl[1,1':4',1'']terphenyl

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND AND USE THEREOF". Paragraph 0243. . Retrieved 2019/02/15.
• 2、 -. "Spirocyclic derivatives". Page/Page column 88. . Retrieved 2016/04/09.