Technology Process of 4-Hexenal, 4-methyl-, (4E)-
There total 1 articles about 4-Hexenal, 4-methyl-, (4E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
periodic acid; 3-chloro-benzenecarboperoxoic acid;
Multistep reaction. Title compound not separated from byproducts;
2.) THF, 0 deg C;
DOI:10.1016/S0040-4020(01)89682-4
- Guidance literature:
-
With
lithium;
In
tetrahydrofuran;
for 3h;
ultrasonic bath;
DOI:10.1002/poc.687
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-BuLi / diethyl ether / -78 °C
1.2: 62 percent / diethyl ether
2.1: 88 percent / Dess-Martin periodinane / CH2Cl2 / 20 °C
3.1: (+)-B-chlorodiisopinocamphenylborane / tetrahydrofuran / -20 °C
4.1: triethylamine; tetra-n-butylammonium bromide / palladium(II) acetate / acetonitrile; H2O
5.1: 98 percent / imidazole; 4-N,N-(dimethylamino)pyridine / CH2Cl2 / 0 °C
With
1H-imidazole; dmap; n-butyllithium; tetrabutylammomium bromide; Dess-Martin periodane; triethylamine; B-chlorodiisopinocampheylborane;
palladium diacetate;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; acetonitrile;
4.1: Heck cyclization;
DOI:10.1021/ja0660507